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Colchicine alters apamin receptors, electrical activity, and skeletal muscle relaxation
(1993)
A low conductance calcium‐activated K+ channel is thought to regulate the rate of firing of several excitable cells. In skeletal muscle the expression of this channel is under nerve control. Previously, we reported that ...
Possible role of apamin‐sensitive K+ channels in myotonic dystrophy
(1994)
Myotonic muscular dystrophy is a genetic disease characterized mainly by muscle atrophy and myotonia, a repetitive electrical activity of muscle. In the present study, the possible role of apamin‐sensitive K+ channels in ...
MECHANISM OF SMOOTH-MUSCLE CONTRACTION AND RELAXATION MEDIATED BY KININ RECEPTOR
(Assoc Bras Divulg Cientifica, 1994-08-01)
The increase in sensitivity of guinea pig preparations to bradykinin (BK) due to stretching occurring with time after mounting was studied by determining the time course of changes in the cell membrane potential, measured ...
Guanethidine effects on the guinea pig vas deferens are antagonized by the blockers of calcium-activated potassium conductance, apamin, methylene blue, and quinine
(1983)
The blocking effects of guanethidine on electrically induced, neurally mediated, contractions of the guinea pig vas deferens in vitro could be markedly antagonized by the bee venom polypeptide apamin (20-60 nM), by 0.1 mM ...
Neural control of the expression of a Ca2+-activated K+ channel involved in the induction of myotonic-like characteristics
(Kluwer Academic/Plenum Publishers, 1996)
1. Expression of the apamin-sensitive K+ channel (SK+) in rat skeletal muscle is neurally regulated. The regulatory effect of the nerve over the expression of some muscle ion channels has been attributed to the electrical ...
Continuous measurement of net potassium movements in rat brain cortex suspensions. Effects of glutamate, veratridine, creatine and other substances
(1986)
Net K fluxes in in vitro suspensions of sliced rat brain cortex were studied by means of a K-sensitive electrode. When incubation was in 3 mM K, a net K efflux occurred. It could be resolved into two first-order rate ...
Age-dependent expression of the apamin-sensitive calcium-activated K+ channel in fast and slow rat skeletal muscle
(Academic Press Inc., 1997)
An altered expression of the apamin-sensitive K+ channel from skeletal muscle is apparently implicated in human myotonic dystrophy (MD). We found, in rats, that the expression of this channel depends on age and the type ...
Efecto de la administración subcrónica de la apamina en ratas viejas sobre la morfología neuronal de la corteza prefrontal, núcleo accumbens e hipocampo ventral
(01/02/2012)
ABSTRACT: Apamin is a neurotoxin extracted from honey bee venom and is a selective blocker of small conductance Ca2+ -activated K+ channels (SK). Several electrophysiological and behavioral studies indicate that apamin may ...
ROLE OF CA2+-DEPENDENT K-CHANNELS IN THE MEMBRANE-POTENTIAL AND CONTRACTILITY OF AORTA FROM SPONTANEOUSLY HYPERTENSIVE RATS
(Stockton Press, 1994-11-01)
1 Contractile responses to KCl and membrane potentials were determined in aortic rings from spontaneously hypertensive rats (SHR), normotensive Wistar rats (NWR) and Wistar Kyoto rats (WKY) both in the absence and in the ...
Effect of angiotensin II, ATP, and ionophore A23187 on potassium efflux in adrenal glomerulosa cells
(1986)
Angiotensin II stimulus on perifused bovine adrenal glomerulosa cells elicited an increase in 86Rb efflux from cells previously equilibrated with the radioisotope. When 45Ca fluxes were measured under similar conditions, ...