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Bioguided study of the Antarctic alga Himantothallus grandifolius (A. Geep & E.S. Geep) indicates 13E-Docosenamide as potential antileishmanial agent
(2020-01-01)
Constant efforts to discover new antileishmanial agents are important because there are only a few available drugs for the treatment of leishmaniasis, which present several drawbacks including high toxicity and difficult ...
Antileishmanial activity of 1,3,4-thiadiazolium-2-aminide in mice infected with Leishmania amazonensis
(American Society for Microbiology, 2018)
Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil
(Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, 2019)
Antileishmanial activity screening of 5-nitro-2-heterocyclic benzylidene hydrazides
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
A series of 53 nitro derivatives rationally designed were obtained by parallel synthesis and screened against Leishmania donovani. Six compounds exhibited IC(50) values lower than standard drugs. Brief SAR analysis revealed ...
2-Substituted quinoline alkaloids as potential antileishmanial drugs
(Antimicrobial Agents and Chemotherapy, 1993-04)
Abstract.
Ten 2-substituted quinoline alkaloids isolated from a plant used for treatment of New World cutaneous leishmaniasis have antileishmanial in vitro activities against the extracellular forms of Leishmania spp. ...
Chalcones and N-acylhydrazones: direct analogues? Exploratory data analysis applied to potential novel antileishmanial agents
(Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, 2010)
Leishmaniasis is an important health and social problem for which there is limited effective therapy. Chalcones and N-acylhydrazones have been studied as promising antileishmanial agents in enzymatic inhibition and in vitro ...
Brazilian propolis antileishmanial and immunomodulatory effects
(2013-06-12)
The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection. The antileishmanial effect of propolis ...
Brazilian propolis antileishmanial and immunomodulatory effects
(2013-06-12)
The antileishmanial and immunomodulatory effects of propolis collected in Botucatu, São Paulo State, Brazil, were evaluated in Leishmania (Viannia) braziliensis experimental infection. The antileishmanial effect of propolis ...
Synthesis, cytotoxicity, antibacterial and antileishmanial activities of imidazolidine and hexahydropyrimidine derivatives
(2013-05-01)
This paper describes the synthesis and in vitro biological activities of imidazolidine and hexahydropyrimidine derivatives against bacteria (Escherichia coli, Staphylococcus aureus and Mycobacterium tuberculosis) and ...