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Synthesis, Surface-Active Properties, and Anthelmintic Activities of New Cationic Gemini Surfactants Against the Gastrointestinal Nematode, Heligmosomoides polygyrus bakeri, In Vitro
(Springer Heidelberg, 2012-03)
A novel series of cationic dimeric surfactants was prepared involving the ketalization reaction, Williamson etherification, and regioselective oxirane ring opening with tertiary alkyl amines. The synthesized compounds were ...
Host pharmacokinetics and drug accumulation of anthelmintics within target helminth parasites of ruminants
(New Zealand Veterinary Assoc Inc, 2017-07)
Anthelmintic drugs require effective concentrations to be attained at the site of parasite location for a certain period to assure their efficacy. The processes of absorption, distribution, metabolism and excretion ...
Essential oils for the discovery of new anthelmintic compounds tested on the nematode Caenorhabditis Elegans
(Fundación Revista Medicina, 2020)
Parasitic nematodes of humans and animals cause dis- eases of major socio-economic importance globally. Con- trol of infections in both human and veterinary medicine currently relies mainly on chemotherapy, but resistance ...
Disclosing the bioactive metabolites involved in the in vitro anthelmintic effects of salt-tolerant plants through a combined approach using PVPP and HPLC-ESI-MSn
(2021-12-01)
Strategies to reduce dependence on synthetic drugs for the treatment of gastrointestinal nematodes (GIN) infections in ruminants include the search for novel anthelmintic scaffolds on plants, yet salt-tolerant plants remain ...
Behavioral and molecular bases of the anthelmintic activity of essential oils explored in the nematode Caenorhabditis elegans
(Fundación Revista Medicina, 2021)
Control of helminth infections in both human and veterinary med icine currently relies mainly on chemotherapy, but acquisition of resistance is an increasing problem that leads to the urgent need of discovery of novel ...
Caenorhabditis elegans serotonin-gated chloride channel MOD-1 as a novel drug target for anthelmintic therapy
(Sociedad Argentina de Biofísica, 2020)
Serotonin-gated ion channels (5-HT3) belong to the family of Cys-loop receptors, which are pentameric proteins that mediate fast synaptic transmission. In mammals, 5-HT3 are non-selective cationic channels that can be ...
Deciphering the molecular mechanisms underlying the anthelmintic effect of essential oils evaluated in Caenorhabditis elegans
(Genetics Society of America, 2021)
Helminths consist of a diverse group of parasitic worms including nematodes, which cause diseases of major socio-economic importance globally. Control of infections in both human and veterinary medicine currently relies ...