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Protocol to refine intestinal motility test in mice
(2004-07-01)
We propose a new protocol intended to conform to the 3Rs (replacement, reduction, and refinement) principle, using animals fasted for 3 h to control intestinal motility, which reduced stress in the animals. In this new ...
Neurochemical, behavioral, and neurogenic validation of a hyposerotonergic animal model by voluntary oral consumption of PCPA
(American Chemical Society, 2020-02)
The inhibitor of tryptophan hydroxylase, para-chlorophenylalanine (PCPA), has been classically employed as a pharmacological tool to deplete serotonin (5-HT) in animal models and to evaluate whether this neurotransmitter ...
Characterization of a refinement of the "pylorus ligation" model of rat gastric ulceration resulting in "no pain" and a more specific pharmacological response
(Elsevier Science IncNew YorkEUA, 2013)
Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms
(2021-11)
The lethality neutralization assay in mice is the gold standard for the evaluation of the preclinical efficacy and
specification fulfillment of snake antivenoms. However, owing to the animal suffering involved, this assay ...
Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation
(2009-10-01)
Tests in animals are used as models in toxicological and investigative studies. However, such tests have been considered inhumane because they can cause pain and suffering to experimental animals, while these methods can ...
Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation
(Universidade de São Paulo (USP), Faculdade de Ciências Farmacêuticas, 2009-12-01)
Testes em animais são utilizados como modelos em estudos toxicológicos e de pesquisa. Entretanto, tais testes têm sido considerados desumanos, porque causam dor e sofrimento aos animais experimentais, porquanto estes métodos ...