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Comparison of isoflurane, halothane and fentanyl in patients with decreased ejection fraction undergoing coronary surgery
(AUSTRALIAN SOC ANAESTHETISTS, 1996)
The aim of the study was to compare three anaesthetic agents in patients with ejection fraction below 0.40 subjected to coronary revascularization surgery. Twenty-five elective coronary surgical patients with ejection ...
Volatile anaesthetics induce biochemical alterations in the heme pathway in a B-lymphocyte cell line established from hepatoerythropoietic porphyria patients (LBHEP) and in mice inoculated with LBHEP cells
(Pergamon-Elsevier Science Ltd, 2004-02)
Hepatoerythropoietic porphyria (HEP) is the homozygous form of Porphyria Cutanea Tarda (PCT), characterized by an accumulation of porphyrins due to uroporphyrinogen decarboxylase deficiency. Fluorinated volatile anaesthetics ...
Effects of volatile anaesthetics on heme metabolism in a murine genetic model of Acute Intermittent Porphyria: A comparative study with other porphyrinogenic drugs
(Elsevier Science, 2018-03)
Background: Acute Intermittent Porphyria (AIP) is an inherited disease produced by a deficiency of Porphobilinogen deaminase (PBG-D). The aim of this work was to evaluate the effects of Isoflurane and Sevoflurane on heme ...
Relevance of cytochrome p450 levels in the actions of enflurane and isoflurane in mice: studies on the haem pathway
(Wiley Blackwell Publishing, Inc, 2001-12)
1. The effect of the fluorinated ether anaesthetics enflurane and isoflurane in mice on haem metabolism and regulation in different metabolic states, such as depression and induction of cytochrome P450 produced by ...
Heme metabolism, oxidative and nitrosative markers in a mouse model of Hemochromatosis: Effect of Isoflurane, ethanol and 5-aminolevulinic acid
(Bioinfo Publications, 2013-12)
Hereditary hemochromatosis (HH) is characterized by iron homeostasis alterations. Association between HH and Porphyria Cutanea Tarda has been reported. The aim was to characterize oxidative and nitrosative stress status ...
Cytochrome P450 expression in mouse brain: specific isoenzymes involved in Phase I metabolizing system of porphyrinogenic agents in both microsomes and mitochondria
(Natl Research Council Canada-n R C Research Press, 2015-02)
Brain cytochrome P450 (CYP) metabolizes a variety of drugs to produce their pharmacological effects within the brain. We have previously observed that porphyrinogenic agents altered CYP levels in brain. The aim of this ...
Anaesthetic drugs and survival: a Bayesian network meta-analysis of randomized trials in cardiac surgery
(Oxford Univ Press, 2013-12-01)
Many studies have compared desflurane, isoflurane, sevoflurane, total i.v. anaesthesia (TIVA), or all in cardiac surgery to assess their effects on patient survival.We performed standard pairwise and Bayesian network ...
Anestésicos volátiles y sus efectos sobre la cadena respiratoria. Regulación de la óxido nítrico sintasa mitocondrialVolatile anaesthetics: Effects on respiratory chain. Regulation of nitric oxide synthase
(2019-03-29)
Las mitocondrias juegan un papel vital en el metabolismo energético; En el interior se produce la fosforilación oxidativa en la cadena de transporte de electrones y la generación de equivalentes de reducción por el ciclo ...
Use of lidocaine, propranolol, amiodarone, and verapamil in toad envenoming (genus bufo) in dogs
(Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, 2001-12)
Toad envenoming in dogs can cause death by cardiac fibrilation (CVF). Traditional therapy consists mainly of atropine and propranolol, the last one used to prevent the CVF, that is preceded by negative ventricular deflections ...
Evaluation of DNA damage and lipoperoxidation of propofol in patients undergoing elective surgery
(Lippincott Williams & Wilkins, 2009-08-01)
Background and objectives Inhaled anaesthetics have been studied regarding their genotoxic and mutagenic potential in vivo. Propofol differs from volatile anaesthetics because it does not show mutagenic effects and it has ...