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Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic
(Springer New York LLC, 2019)
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.Aminochrome induces neurotoxic alpha-synuclein oligomer formation relevant to the etiology of Parkinson’s disease. Oxidative stress produces aminochrome ...
Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson’s disease
(Taylor and Francis Ltd, 2017)
Copyright © 2016 Informa UK Limited, trading as Taylor & Francis Group.Neuromodulation by spinal cord stimulation has been proposed as a symptomatic treatment for Parkinson’s disease. We tested the chronic effects of spinal ...
Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
(Public Library of Science, 2015-04)
There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive ...
Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment
(Elsevier Science Inc, 2018-08)
α-synuclein is involved in both familial and sporadic Parkinson's disease. Although its interaction with mitochondria has been well documented, several aspects remains unknown or under debate such as the specific ...
Drp-1 dependent mitochondrial fragmentation and protective autophagy in dopaminergic SH-SY5Y cells overexpressing alpha-synuclein
(Academic Press Inc Elsevier Science, 2018-04)
Parkinson's disease is a neurodegenerative movement disorder caused by the loss of dopaminergic neurons from substantia nigra. It is characterized by the accumulation of aggregated α-synuclein as the major component of the ...
Features of alpha-synuclein that could explain the progression and irreversibility of parkinson´s disease.
(2015)
Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system, and it is the main component of Lewy bodies, one of the histopathological features of Parkinson's disease (PD) which is a progressive ...
DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers
(Springer New York LLC, 2017)
© 2017, Springer Science+Business Media New York. Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both ...
DT-diaphorase protects against autophagy induced by aminochrome dependent alpha synuclein oligomers
(Springer, 2017)
Alpha-synuclein (SNCA) oligomers have been reported to inhibit autophagy. Aminochrome-induced SNCA oligomers are neurotoxic, but the flavoenzyme DT-diaphorase prevents both their formation and their neurotoxicity. However, ...
Extracellular alpha-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane.
(2015)
It has been postulated that the accumulation of extracellular alpha-synuclein (alpha-syn) might alter the neuronal membrane by formation of 'pore-like structures' that will lead to alterations in ionic homeostasis. However, ...
Motor Deficits And Beta Oscillations Are Dissociable In An Alpha-Synuclein Model Of Parkinson's Disease
(2017)
Parkinson's disease (PD) is a neurodegenerative disorder characterised by progressive motor symptoms resulting from chronic loss of dopaminergic neurons in the nigrostriatal pathway. The over expression of the protein ...