Buscar
Mostrando ítems 1-10 de 18
Identification of threonine 422 in transmembrane domain αM4 of the nicotinic acetylcholine receptor as a possible site of interaction with hydrocortisone
(Pergamon-Elsevier Science Ltd, 2002-07)
The modulatory effects exerted by the glucocorticoid hydrocortisone (HC) on the nicotinic acetylcholine receptor (AChR) were studied in mutants of the α subunit M4 transmembrane region. Based on the photoaffinity labeling ...
Alanine Scanning Mutagenesis of the C-Terminal Cytosolic End of Gpm6a Identifies Key Residues Essential for the Formation of Filopodia
(Frontiers Research Foundation, 2018-09)
Neuronal membrane glycoprotein M6a (Gpm6a) is a protein with four transmembrane regions and the N- and the C-ends facing the cytosol. It functions in processes of neuronal development, outgrowth of neurites, and formation ...
The catalytic and other residues essential for the activity of the midgut trehalase from Spodoptera frugiperda
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
Trehalase (EC 3.2.1.28) hydrolyzes only alpha, alpha`- trehalose and is present in a variety of organisms, but is most important in insects and fungi. Crystallographic data showed that bacterial trehalase has 0312 and E496 ...
Highly conserved motifs within the large Sec7 ARF guanine nucleotide exchange factor GBF1 target it to the Golgi and are critical for GBF1 activity
(American Physiological Society, 2018-06)
Cellular life requires the activation of the ADP-ribosylation factors (ARFs) by Golgi brefeldin A-resistant factor 1 (GBF1), a guanine nucleotide exchange factor (GEF) with a highly conserved catalytic Sec7 domain (Sec7d). ...
An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus
(American Society of MicrobiologyWashington, DC, 2010-12)
We have previously reported the establishment of a Staphylococcus aureus laboratory strain, 10*3d1, having reduced susceptibility to daptomycin and heterogeneous vancomycin-intermediate S. aureus (VISA) phenotype. The ...
A single serine residue determines selectivity to monovalent metal ions in metalloregulators of the MerR family
(American Society for Microbiology, 2015-05)
MerR metalloregulators alleviate toxicity caused by an excess of metal ions, such as copper, zinc, mercury, lead, cadmium, silver, or gold, by triggering the expression of specific efflux or detoxification systems upon ...
Bioinformatic and mutational analysis of ophiovirus movement proteins, belonging to the 30K superfamily
(Academic Press Inc Elsevier Science, 2016-11)
Ophioviridae is a family of segmented, negative-sense, single-stranded RNA plant viruses. We showed that their cell-to-cell movement protein (MP) is an isolated member of the 30K MP superfamily with a unique structural ...
Estudio del residuo serina 370 en el mecanismo de reacción de la enzima alcohol aciltransferasa de Vasconcellea pubescens
(Universidad de Talca (Chile). Escuela de Bioinformática., 2014)