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Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages
(Rockefeller University Press, 2020)
Phagocytes use their actomyosin cytoskeleton to migrate as well as to probe their environment by phagocytosis or macropinocytosis. Although migration and extracellular material uptake have been shown to be coupled in some ...
Intramolecular loop/tail interactions are essential forconnexin 43-hemichannel activity
(2010)
Connexin-assembled gap junctions (GJs) and hemichannels coordinate intercellular signaling processes. Although the regulation of connexins in GJs has been well characterized, the molecular determinants controlling ...
Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus
(2021-09)
Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes. They are known to induce skeletal muscle ...
Diverse patterns of molecular changes in the mechano-responsiveness of focal adhesions
(Nature Publishing Group, 2018-12)
Focal adhesions anchor contractile actin fibers with the extracellular matrix, sense the generated tension and respond to it by changing their morphology and composition. Here we ask how this mechanosensing is enabled at ...
Mechanical alterations in airway smooth muscle after interaction with indoor pollutant - A mathematical model
(Águas de Lindóia, 2014-02-20)
The viscoelasticity of mammalian lung is determined by the mechanical properties and structural regulation of the airway smooth muscle (ASM). The exposure to polluted air may deteriorate these properties with harmful ...
Mechanical Alterations in airway smooth muscle after interaction with indoor pollutant – A mathematical model.
(Sociedade Brasileira de FísicaÁguas de Lindóia, 2013-05-13)
The viscoelasticity of mammalian lung is determined by the mechanical properties and structural regulation of the airway smooth muscle (ASM). The exposure to polluted air may deteriorate these properties with harmful ...
p53 related protein kinase is required for Arp2/3-dependent actin dynamics of hemocytes in drosophila melanogaster
(Frontiers Media, 2022)
Cells extend membrane protrusions like lamellipodia and filopodia from the leading edge to sense, to move and to form new contacts. The Arp2/3 complex sustains lamellipodia formation, and in conjunction with the actomyosin ...