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Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines
(Impact Journals LLC, 2017-10)
Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia. Here we show the antitumoral activity ...
Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells
(Dove Press, 2014-07)
Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases ...
Desarrollo de nuevos inhibidores de Rho GTPasas con actividad antitumoral mediante un screening virtual basado en docking
(Universidad Nacional de Quilmes, 2014-06-27)
La vía de señalización de las Rho GTPasas cumple un rol fundamental en la regulación de múltiples procesos celulares. La activación aberrante de Rac1, un miembro de la familia de las Rho GTPasas, está asociado con ...
Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines
(Bentham Science Publishers, 2013-09)
Rho GTPases play a key role in the regulation of multiple essential cellular processes, including actin dynamics, gene transcription and cell cycle progression. Aberrant activation of Rac1, a member of Rho family of small ...
Photoinjection of High Potential Holes into Cu5Ta11O30 Nanoparticles by Porphyrin Dyes
(American Chemical Society, 2015-09)
Excited-state hole injection into the valence band of Cu5Ta11O30 nanoparticles (NP-Cu5Ta11O30) was investigated through sensitization with zinc porphyrin dyes using simulated solar irradiance. The Cu5Ta11O30 nanoparticles ...