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Xestospongin B, a competitive inhibitor of IP3-mediated Ca2+ signalling in cultured rat myotubes, isolated myonuclei, and neuroblastoma (NG108-15) cells
(ELSEVIER SCIENCE BV, 2005-04-11)
Xestospongin B, a macrocyclic bis-1-oxaquinolizidine alkaloid extracted from the marine sponge Xestospongia exigua, was highly purified and tested for its ability to block inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ ...
Mitochondrial Ca2+ signals in autophagy
(Elsevier Ltd, 2012)
Macroautophagy (autophagy) is a lysosomal degradation pathway that is conserved from yeast to humans that plays an important role in recycling cellular constituents in all cells. A number of protein complexes and signaling ...
Alcaloides bioactifs extraits d´éponges: les xestospongines dans l´étude de la signalisation du Ca2+ intracellulaire dépendante de l´inositol 1,4,5-triphosphate
(Goudey-Perriere, F.Benoit, E.Puiseux-Dao, S.Bon, C.Editions Lavoisier, 2004)
Alcaloides bioactifs extraits d´éponges: les xestospongines dans l´étude de la signalisation du Ca2+ intracellulaire dépendante de l´inositol 1,4,5-triphosphateRencontres en Toxinologie
(Goudey-Perriere, F.Benoit, E.Puiseux-Dao, S.Bon, C.Editions Lavoisier, 2020)
Inhibition of InsP3R with xestospongin B reduces mitochondrial respiration and induces selective cell death in T cell acute lymphoblastic leukemia cells
(MDPI, 2021)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy
whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic
treatments. Mitochondrial ...
Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells
(MDPI, 2021-01)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial ...
Regulación de la autofagia por el receptor del inositol trisfosfato (IP3R)
(Universidad de ChileCyberDocs, 2009)
La macroautofagia, comúnmente referida como “autofagia” es la principal vía de degradación de proteínas, organelos y material citoplasmático, permitiendo de este modo el reciclaje del material intracelular. Este proceso ...
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
(NATURE PUBLISHING GROUP, 2009-07)
The inositol 1,4,5-trisphosphate receptor (IP3R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca2+) transients from the endoplasmic ...
Localized nuclear and perinuclear Ca2+ signals in intact mouse skeletal muscle fibers
(Frontiers Media, 2015)
Nuclear Ca2+ is important for the regulation of several nuclear processes such as gene expression. Localized Ca2+ signals (LCSs) in skeletal muscle fibers of mice have been mainly studied as Ca2+ release events from the ...
Participación de la vía transduccional IP3-Receptor de IP3-Calcio en la acción de insulina en células musculares esqueléticas
(Universidad de Chile, 2011)
El músculo esquelético, uno de los principales tejidos sensibles a
insulina, es el principal encargado del mantenimiento de la homeostasis de la
glucosa, disponiendo de alrededor de un 80% de la glucosa circulante
postprandial, ...