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Xeroderma pigmentosum: Low prevalence of germline XPA mutations in a brazilian XP population
(2015-04-01)
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by DNA repair defects that cause photophobia, sunlight-induced cancers, and neurodegeneration. Prevalence of germline mutations in the nucleotide ...
Impacto da deficiência de XPA na regulação de NFE2L2 e Proteassoma
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOQUÍMICA, 2018-11-23)
During the cell cycle, reactive oxygen species (ROS) are generated mainly by
normal mitochondrial activity. Among the ROS, hydrogen peroxide (H₂O₂) is
considered to be one of the main agents in cellular processes such ...
Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions
(ELSEVIER IRELAND LTDCLARE, 2012)
Doxorubicin (DOX) is an important tumor chemotherapeutic agent, acting mainly by genotoxic action. This work focus on cell processes that help cell survival, after DOX-induced DNA damage. In fact, cells deficient for XPA ...
Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions
(Elsevier B.V., 2012-01-01)
Doxorubicin (DOX) is an important tumor chemotherapeutic agent, acting mainly by genotoxic action. This work focus on cell processes that help cell survival, after DOX-induced DNA damage. in fact, cells deficient for XPA ...
Modulação da expressão da proteína XPA em resposta ao tratamento com azul de metileno fotossensibilizado
(Universidade Federal do Rio Grande do NorteBRUFRNPrograma de Pós-Graduação em BioquímicaBioquímica; Biologia Molecular, 2010-10-06)
Reactive oxygen species (ROS) are produced by aerobic metabolism and react with biomolecules, such as lipids, proteins and DNA. In high concentration, they lead to oxidative stress. Among ROS, singlet oxygen (1O2) is one ...
XPA deficiency affects the ubiquitin-proteasome system function
(Elsevier, 2020)