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Light modulates the melanophore response to alpha-MSH in Xenopus laevis: An analysis of the signal transduction crosstalk mechanisms involved
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
Melanin granule (melanosome) dispersion within Xenopus laevis melanophores is evoked either by light or alpha-MSH. We have previously demonstrated that the initial biochemical steps of light and alpha-MSH signaling are ...
The expression of melanopsin and clock genes in Xenopus laevis melanophores and their modulation by melatonin
(Associação Brasileira de Divulgação Científica, 2012)
Vertebrates have a central clock and also several peripheral clocks. Light responses might result from the integration of light signals by these clocks. The dermal melanophores of Xenopus laevis have a photoreceptor molecule ...
Exchange of microtubule molecular motors during melanosome transport in Xenopus laevis melanophores is triggered by collisions with intracellular obstacles
(Humana Press, 2008-12)
The observation that several cargoes move bidirectionally along microtubules in vivo raised the question regarding how molecular motors with opposed polarity coordinate during transport. In this work, we analyzed the switch ...
Regulation of Melanopsins and Per1 by α-MSH and Melatonin in Photosensitive Xenopus laevis Melanophores
(Hindawi Publishing CorporationNew York, 2014)
α-MSH and light exert a dispersing effect on pigment granules of Xenopus laevis melanophores; however, the intracellular signaling pathways are different. Melatonin, a hormone that functions as an internal signal of darkness ...
Endothelin modulates the circadian expression of non-visual opsins
(Maryland Heights, 2014-05-09)
The non-visual opsin, melanopsin, expressed in the mammalian retina, is considered a circadian photo- 24
pigment because it is responsible to entrain the endogenous biological clock. This photopigment is also 25
present ...
Melanosomes transported by myosin-V in xenopus melanophores perform slow 35 nm steps
(Cell Press, 2006-12)
We studied the motion of pigment organelles driven by myosin-V in Xenopus melanophores using a tracking technique with precision of 2 nm. The organelle trajectories showed occasional steps with a distribution centered at ...
Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport
(Elsevier Science, 2015-07)
The mechanisms involved in bidirectional transport along microtubules remain largely unknown. We explored the collective action of kinesin-2 and dynein motors during transport of melanosomes in Xenopus laevis melanophores. ...
Anomalous dynamics of melanosomes driven by myosin-V in Xenopus laevis melanophores
(Cell Press, 2009-09)
The organization of the cytoplasm is regulated by molecular motors, which transport organelles and other cargoes along cytoskeleton tracks. In this work, we use single particle tracking to study the in vivo regulation of ...
Extracting the stepping dynamics of molecular motors in living cells from trajectories of single particles
(Springer, 2013-01)
Molecular motors are responsible of transporting a wide variety of cargos in the cytoplasm. Current efforts are oriented to characterize the biophysical properties of motors in cells with the aim of elucidating the mechanisms ...
Organelle transport along microtubules in Xenopus melanophores: Evidence for cooperation between multiple motors
(Elsevier, 2006-12)
Xenopus melanophores have pigment organelles or melanosomes which, in response to hormones, disperse in the cytoplasm or aggregate in the perinuclear region. Melanosomes are transported by microtubule motors, kinesin-2 and ...