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The selective glucocorticoid receptor modulator CORT108297 restoresfaulty hippocampal parameters in Wobbler andcorticosterone-treated mice
(Elsevier, 2014-09)
Mutant Wobbler mice are models for human amyotrophic lateral sclerosis (ALS). In addition to spinal cord degeneration, Wobbler mice show high levels of blood corticosterone, hyperactivity of the hypothalamic-pituitary-adrenal ...
The delective glucocorticoid receptor modulator cort 113176 reduces neurodegeneration and neuroinflammation in Wobbler mice spinal cord
(Pergamon-Elsevier Science Ltd, 2018-08)
Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show ...
The Progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in Wobbler Mouse motoneuron degeneration
(Elsevier, 2015-11-12)
Wobbler mutant mice suffer from progressive motoneuron degeneration and glial cell reactivity in the spinal cord. To prevent development of these abnormalities, we employed Nestorone, a high-affinity progesterone receptor ...
Progesterone restores retrograde labelling of cervical motoneurons in Wobbler mouse motoneuron disease
(Academic Press Inc Elsevier Science, 2005-10)
The Wobbler mouse, a mutant characterized by motoneuron degeneration in the cervical spinal cord, has been used to test the efficacy of novel treatments for human motoneuron diseases (HMD). Previous reports have shown that ...
Progesterone attenuates several hippocampal abnormalities of the Wobbler mouse
(Wiley, 2013-02-24)
It is now recognised that progesterone plays a protective role for diseases of the central nervous system. In the Wobbler mouse, a model of motoneurone degeneration, progesterone treatment prevents spinal cord neuropathology ...
Basis of progesterone protection in spinal cord neurodegeneration
(Pergamon-Elsevier Science Ltd., 2003-01)
Progesterone neuroprotection has been reported in experimental brain, peripheral nerve and spinal cord injury. To investigate for a similar role in neurodegeneration, we studied progesterone effects in the Wobbler mouse, ...
Progesterone neuroprotection in the Wobbler mouse, a genetic model of spinal cord motor neuron disease
(Elsevier Science, 2002)
Motor neuron degeneration characterizes the spinal cord of patients with amyotrophic lateral sclerosis and the Wobbler mouse mutant. Considering that progesterone (PROG) provides neuroprotection in experimental ischemia ...
Steroid profiling in male wobbler mouse, a model of Amyotrophic Lateral Sclerosis
(Endocrine Society, 2016-11-01)
The Wobbler mouse is an animal model for human motoneuron diseases, especially amyotrophic lateral sclerosis (ALS), used in the investigation of both pathology and therapeutic treatment. ALS is a fatal neurodegenerative ...
Progesterone and Allopregnanolone Neuroprotective Effects in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis
(Springer/Plenum Publishers, 2021-06)
Progesterone regulates a number of processes in neurons and glial cells not directly involved in reproduction or sex behavior. Several neuroprotective effects are better observed under pathological conditions, as shown in ...
Progesterone treatment reduces NADPH-diaphorase/Nitric oxide synthase in Wobbler mouse motoneuron disease
(Elsevier Science, 2004-12)
Previous work demonstrated that progesterone (PROG) treatment attenuates morphological, molecular and functional abnormalities in the spinal cord of the Wobbler (Wr) mouse, a genetic model of motoneuron degeneration. Wr ...