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Withanolides and related steroids
(Springer, 2011-10)
Since the isolation of the first withanolides in the mid-1960s, over 600 new members of this group of compounds have been described, with most from genera of the plant family Solanaceae. The basic structure of withaferin ...
Withalutin, a new cytotoxic withanolide from Athenaea velutina (Sendtn.) D'Arcy
(Taylor & Francis Health Sciences, 2022)
Withanolid amine and nicotine from Dunalia spinosa (Solanaceae) Amino-witanólido y nicotina de Dunalia spinosa (Solanaceae)
(2012)
A new withanolid amine was isolated from Dunalia spinosa (Solanaceae). Its relative stereochemistry was determined using FT-IR, 1H and 13C NMR spectroscopies and high resolution mass spectrometry. Nicotine was also isolated; ...
A Withanolide-rich Fraction of Athenaea velutina Induces Apoptosis and Cell Cycle Arrest in Melanoma B16F10 Cells
(2021-01-01)
Athenaea velutina is a promising Brazilian shrub with cytotoxic and antimigratory properties against cancer cells. However, the mechanism of induction of cancer cell death and the compounds involved remain unknown. To ...
Phytotoxic withanolides from Jaborosa rotacea
(AMER CHEMICAL SOC, 2006-05-26)
Twelve new withanolides were isolated from the aerial part of Jaborosa rotacea: five had a spiranoid delta-lactone ( 1- 5); one contained a 26,12-delta-lactone and a C-12-C-23 bond ( 6); five corresponded to trechonolide-type ...
Selective antiproliferative withanolides from species in the genera Eriolarynx and Deprea
(American Chemical Society, 2019-05)
Four new withanolides (2−5), together with 4β,7β,20-trihydroxy-1-oxowitha-2,5,24-trienolide (1), were isolated from the aerial parts of Eriolarynxiochromoides. The antiproliferative activity of all compounds purified from ...
Antiproliferative activity of withanolides against human breast cancer cell lines
(American Chemical Society, 2010-05)
The in vitro antiproliferative activity of a series of 22 naturally occurring withanolides was examined against the T-47D, MCF7, MCF7/BUS, MDA-MB-231, and SK-Br-3 human solid tumor breast cancer cell lines. The most active ...
Withanolides with antibacterial activity from Nicandra john-tyleriana
(American Chemical Society, 2015-02-10)
Eleven new withanolides (1-11) were isolated and characterized from the aerial parts of Nicandra john-tyleriana. Five of these withanolides have an unmodified skeleton (1-5), two are acnistins (6, 7), and four are withajardins ...
Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells
(American Chemical Society, 2013)
Recently, our group reported the discovery of three new withanolides, physangulidines A–C, from Physalis angulata. In this study, the biological effects of physangulidine A (1), which was the most active and abundant of ...
Physangulidines A, B, and C: Three new antiproliferative withanolides from Physalis angulata L.
(American Chemical Society, 2012)
Bioassay-directed fractionation of the whole plant of Physalis angulata L. afforded three new antiproliferative withanolides with an unusual carbon framework: physangulidines A (1), B (2), and C (3). Structures of the three ...