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Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
(Springer Nature, 2018)
To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A ...
How bioinformatics enables livestock applied sciences in the genomic era
(2012-09-05)
This review paper presents the three main approaches currently used in livestock genomic sciences where the bioinfomatics plays a critical role. They are named as Genomic Selection (GS), Genome Wide Association Study (GWAS) ...
How bioinformatics enables livestock applied sciences in the genomic era
(2012-09-05)
This review paper presents the three main approaches currently used in livestock genomic sciences where the bioinfomatics plays a critical role. They are named as Genomic Selection (GS), Genome Wide Association Study (GWAS) ...
A genome-wide association study of asthma symptoms in Latin American children
(BioMed Central, 2015-12)
A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features
(Springer Nature, 2016)
We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial hair (beard thickness, monobrow, eyebrow thickness). We found 18 signals of ...
Genome-wide association study and heritability estimate for ectopic ureters in Entlebucher mountain dogs
(2018-12-01)
An ectopic ureter is a congenital anomaly which may lead to urinary incontinence and without a surgical intervention even to end-stage kidney disease. A genetic component contributes to the development of this anomaly in ...
Genome-wide association study for feedlot average daily gain in Nellore cattle (Bos indicus)
(Wiley-Blackwell, 2014-06-01)
The genome-wide association study (GWAS) results are presented for average daily gain (ADG) in Nellore cattle. Phenotype of 720 male Bos indicus animals with information of ADG in feedlots and 354147 single-nucleotide ...
Genome-Wide Epigenetic Signatures of Adaptive Developmental Plasticity in the Andes
(Oxford University Press, 2020)
High-altitude adaptation is a classic example of natural selection operating on the human genome. Physiological and genetic adaptations have been documented in populations with a history of living at high altitude. However, ...
Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetes
(Lippincott Williams, 2009-05)
Purpose: We present an approach to prioritize single nucleotide polymorphisms for further follow-up in genome-wide association studies of type 2 diabetes. Method: The proposed method combines both the use of open data ...
Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci
(PLoS, 2023)
Human ear morphology, a complex anatomical structure represented by a multidimensional set of correlated and heritable phenotypes, has a poorly understood genetic architecture. In this study, we quantitatively assessed 136 ...