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Reliable local dynamics in the brain across sessions are revealed by whole-brain modeling of resting state activity
(Wiley-liss, div John Wiley & Sons Inc., 2019-03)
Resting state fMRI is a tool for studying the functional organization of the human brain. Ongoing brain activity at “rest” is highly dynamic, but procedures such as correlation or independent component analysis treat ...
Perturbation of whole-brain dynamics in silico reveals mechanistic differences between brain states
(Academic Press, 2018-04)
Human neuroimaging research has revealed that wakefulness and sleep involve very different activity patterns. Yet, it is not clear why brain states differ in their dynamical complexity, e.g. in the level of integration and ...
Whole-Brain Models to Explore Altered States of Consciousness from the Bottom Up
(MDPI, 2020)
The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain ...
Novel intrinsic ignition method measuring local-global integration characterizes wakefulness and deep sleep
(Society for Neuroscience, 2017-09)
A precise definition of a brain state has proven elusive. Here, we introduce the novel local-global concept of intrinsic ignition characterizing the dynamical complexity of different brain states. Naturally occurring ...
Whole-brain models to explore altered states of consciousness from the bottom up
(Molecular Diversity Preservation International, 2020-09)
The scope of human consciousness includes states departing from what most of us experience as ordinary wakefulness. These altered states of consciousness constitute a prime opportunity to study how global changes in brain ...
Increased Stability and Breakdown of Brain Effective Connectivity during Slow-Wave Sleep: Mechanistic Insights from Whole-Brain Computational Modelling
(Nature Publishing Group, 2017-12)
Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying ...
Awakening: Predicting external stimulation to force transitions between different brain states
(National Academy of Sciences, 2019-09)
A fundamental problem in systems neuroscience is how to force a transition from one brain state to another by external driven stimulation in, for example, wakefulness, sleep, coma, or neuropsychiatric diseases. This requires ...
Modeling regional changes in dynamic stability during sleep and wakefulness
(Elsevier, 2020-07-15)
Global brain states are frequently placed within a unidimensional continuum by correlational studies, ranging from states of deep unconsciousness to ordinary wakefulness. An alternative is their multidimensional and ...
A mechanistic model of the neural entropy increase elicited by psychedelic drugs
(Nature.com, 2020)
Psychedelic drugs, including lysergic acid diethylamide and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological ...