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Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs
(Wiley, 2013-09)
We hypothesized that inhibiting molecules that mediate the adaptation response to cellular stress can antagonize the resistance of pancreatic cancer cells to chemotherapeutic drugs. Toward this end, here, we investigated ...
Estudio del rol de la proteína VMP1 en los procesos de autofagia, muerte y sobrevida celular en la fisiopatología pancreáticaStudy of the role of protein VMP1 in the process of autophagy, death and cell survival in the pancreatic physiopathology
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2010)
The VMP1-Beclin 1 interaction regulates autophagy induction
(Nature Publishing Group, 2013-01-11)
VMP1 is a new player in the regulation of the autophagy-specific phosphatidylinositol 3-kinase complex activation
(Taylor & Francis, 2013-04-04)
We have elucidated a novel mechanism through which the autophagy-specific class III phosphatidylinositol 3-kinase (PtdIns3K) complex can be recruited to the PAS in mammalian cells, through the interaction between BECN1 and ...
A Novel E2F1-EP300-VMP1 Pathway Mediates Gemcitabine-Induced Autophagy in Pancreatic Cancer Cells Carrying Oncogenic KRAS
(Frontiers Media S.A., 2020-06)
Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular constituents, which participates in cell response to disease. We previously characterized VMP1 (Vacuole Membrane Protein 1) as an essential ...
A novel HIF-1α/VMP1-Autophagic Pathway Induces Resistance to Photodynamic Therapy in Colon Cancer Cells.
(Royal Society of Chemistry, 2017-08)
Colon cancer is the third most frequent cancer and the fourth most common cause of cancer-related mortality worldwide and the standard therapy is surgical resection plus adjuvant chemotherapy. Photodynamic therapy (PDT) ...