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Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors
(Instituto Oswaldo Cruz, Ministério da Saúde, 2013-02-01)
The goal of treatment of chronic hepatitis C is to achieve a sustained virological response, which is defined as exhibiting undetectable hepatitis C virus (HCV) RNA levels in serum following therapy for at least six months. ...
Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors
(Instituto Oswaldo Cruz, Ministério da Saúde, 2013-02-01)
The goal of treatment of chronic hepatitis C is to achieve a sustained virological response, which is defined as exhibiting undetectable hepatitis C virus (HCV) RNA levels in serum following therapy for at least six months. ...
QSAR and docking studies of HCV NS3 serine protease inhibitors
(Bentham Science, 2018)
Effectiveness of commercial inhibitors against subtype F HIV-1 protease
(TAYLOR & FRANCIS LTD, 2009)
Subtype F wild type HIV protease has been kinetically characterized using six commercial inhibitors (amprenavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir) commonly used for HIV/AIDS treatment, as well as ...
Variability and resistance mutations in the hepatitis C virus NS3 protease in patients not treated with protease inhibitors
(Instituto Oswaldo Cruz, Ministério da Saúde, 2014)
High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti
(Int Union Crystallography, 2017)
Blood-feeding exoparasites are rich sources of protease inhibitors, and the mosquito Aedes aegypti, which is a vector of Dengue virus, Yellow fever virus, Chikungunya virus and Zika virus, is no exception. AaTI is a ...
Association between the use of protease inhibitors in highly active antiretroviral therapy and incidence of diabetes mellitus and/or metabolic syndrome in HIV-infected patients: A systematic review and meta-analysis
(SAGE Publications Ltd, 2018-04)
This systematic review and meta-analysis tries to determine whether there is an association between the use of protease inhibitors (PIs) and the incidence of diabetes mellitus (DM) and/or metabolic syndrome (MS) in ...
Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors
(2021-04-01)
Although the widespread epidemic of Zika virus (ZIKV) and its neurological complications are well-known there are still no approved drugs available to treat this arboviral disease or vaccine to prevent the infection. ...