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Decreased cGMP Level Contributes to Increased Contraction in Arteries From Hypertensive Rats Role of Phosphodiesterase 1
(LIPPINCOTT WILLIAMS & WILKINS, 2011)
Recent evidence suggests that angiotensin II (Ang II) upregulates phosphodiesterase (PDE) 1A expression. We hypothesized that Ang II augmented PDE1 activation, decreasing the bioavailability of cyclic guanosine 3` ...
Desenvolvimento tecnológico de nanocápsulas para a liberação controlada do neuroprotetor vimpocetina
(Universidade Federal de Santa MariaBrasilFarmacologiaUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2015-05-27)
The Vinpocetine is a synthetic derivative of the vincamine alkaloid, which has a significant neuroprotective effect and is used in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's, as well ...
Desenvolvimento de comprimidos de vimpocetina associada a nanocápsulas poliméricas
(Universidade Federal de Santa MariaBrasilFarmáciaUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2016-05-20)
Vinpocetine is a derivative of the alkaloid vincamine, widely used for the treatment of cerebrovascular and cognitive disorders due to strong neuroprotective effect. Furthermore, Vinpocetine has also antioxidant, ...
Investigação de metabólitos secundários de Tabernaemontana catharinensis A. DC. – (Apocynaceae) e suas potenciais atividades antimicrobianas
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2018-07-17)
The phytochemical investigation of hexane and methanolic crude extracts and their fractions from the
bark of the stem of Tabernaemontana catharinensis (Apocynaceae, commonly known as cobrina) led
to the isolation of nine ...
Desenvolvimento de nanocápsulas poliméricas com diferentes revestimentos para a liberação cerebral de vimpocetina
(Universidade Federal de Santa MariaBrasilAnálises Clínicas e ToxicológicasUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2018-02-02)
Vinpocetine (VP) is used in neurodegenerative diseases, and researches have
indicated a promising anticonvulsant effect of this drug. However, it shows some limitations as
low aqueous solubility and short half-life. ...
Nanocápsulas de poli(ɛ-caprolactona) contendo vimpocetina: desenvolvimento e avaliação da atividade anticonvulsivante
(Universidade Federal de Santa MariaBrasilDesenvolvimento e Avaliação de Produtos FarmacêuticosUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2017-02-13)
Epilepsy is a disease characterized by convulsive seizures, caused by an excessive neuronal electrical discharge, which affects 50 million people worldwide. Vinpocetine, derived from the alkaloid vincamine, is a neuroprotective ...
A novel PDE1A coupled to M2AChR at plasma membranes from bovine tracheal smooth muscle
(Journal of Receptors and Signal Transduction, 2016)
A NOVEL PDE1A COUPLED TO M2AChR AT PLASMA MEMBRANES FROM BOVINE TRACHEAL SMOOTH MUSCLE
(Journal of Receptors and Signal Transduction, 2017)
Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi
(Portland Press, 2004-02)
Compartmentalization of cAMP phosphodiesterases plays a key role in the regulation of cAMP signalling in mammals. In the present paper, we report the characterization and subcellular localization of TcPDE1, the first ...