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Effects of Exercise Training on Hepatic Microsomal Triglyceride Transfer Protein Content in Rats
(GEORG THIEME VERLAG KG, 2009)
Microsomal triglyceride transfer protein (MTP) is a protein that exerts a central regulatory role in very-low-density lipoprotein (VLDL) assembly and secretion. The purpose of the study was to investigate the effects of ...
Supplementation with n-3, n-6, n-9 fatty acids in an insulin-resistance animal model: Does it improve VLDL quality?
(Royal Society of Chemistry, 2017-05)
Insulin-resistance (IR), of increased cardiovascular risk, is characterized by the production of altered VLDL with greater atherogenicity. Dietary fatty acids influence the type of circulating VLDL. But, it is not clear ...
Overproduction of altered VLDL in an insulin-resistance rat model: Influence of SREBP-1c and PPAR-α
(Elsevier Doyma Sl, 2015-07)
Background: In insulin-resistance, VLDL presents alterations that increase its atherogenic potential. The mechanism by which insulin-resistance promotes the production of altered VLDL is still not completely understood. ...
Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003)
We examined in vivo a role for sterol carrier protein-2 (SCP-2) in the regulation of lipid secretion across the hepatic sinusoidal and canalicular membranes. Recombinant adenovirus Ad.rSCP2 was used to overexpress SCP-2 ...
Cholecystectomy increases hepatic triglyceride content and very-low-density lipoproteins production in mice
(WILEY, 2011)
Background & aims: Bile acid (BA) pool size remains unchanged after cholecystectomy (XGB) but it circulates faster, exposing the enterohepatic system to an increased flux of BA. Triglyceride (TG) and BA metabolisms are ...
Inactivation of hepatic microsomal triglyceride transfer protein protects mice from diet-induced gallstones
(W B SAUNDERS CO-ELSEVIER INC, 2006)
Background & Aims: Microsomal triglyceride transfer protein (MTTP) is critical for the production of very-low-density lipoproteins (VLDL). The current studies were undertaken to examine the in vivo role of MTTP in hepatic ...