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VKORC1 polymorphisms in Brazilians: comparison with the Portuguese and Portuguese-speaking Africans and pharmacogenetic implications
(FUTURE MEDICINE LTD, 2010)
Aims: The heterogeneity of the Brazilian population renders the extrapolation of pharmacogenomic data derived from well-defined ethnic groups inappropriate. We investigated the influence of self-reported `race/color`, ...
Efficacy of anticoagulant drugs as rodenticides and genetic variation on Vkorc1 of Mus musculus from Buenos Aires Province (Argentina).
(Revista de la Sociedad Argentina de Genética., 2013-07)
The relationship between anticoagulant rodenticides and the gene for vitamin K epoxide reductase has been extensively studied. The significance of mutations in Vkorc1 on the degree of response to anticoagulants is ...
Efecto de las variantes de VKORC1 y CYP2C9 sobre la dosis de anticoagulantes orales en individuos chilenos
(Sociedad Medica de Santiago, 2015)
BACKGROUND:
The dose of oral anticoagulants (OAC) shows great variability among patients. Pharmacogenetic studies have shown that common variants in genes CYP2C9 (*2 and *3) and VKORC1 (-1639G>A) are associated with lower ...
Efecto de las variantes de VKORC1 y CYP2C9 sobre la dosis de anticoagulantes orales en individuos chilenos
(Sociedad Medica de Santiago, 2015)
BACKGROUND:
The dose of oral anticoagulants (OAC) shows great variability among patients. Pharmacogenetic studies have shown that common variants in genes CYP2C9 (*2 and *3) and VKORC1 (-1639G>A) are associated with lower ...
Influência de polimorfismos nos genes CYP2C9, VKORC1, MDR1 e APOE e variáveis sociodemográficas e clínicas na dose de varfarina em pacientes atendidos em três clínicas de anticoagulação em Belo Horizonte-MG
(Universidade Federal de Minas GeraisBrasilMEDICINA - FACULDADE DE MEDICINAPrograma de Pós-Graduação em Ciências da Saúde - Infectologia e Medicina TropicalUFMG, 2018-07-10)
Warfarin is the most widely used oral anticoagulant for treatment and prevention of thromboembolic disorders. Therapy monitoring is performed using International Normalized Ratio (INR), and time in therapeutic range (TTR) ...
Avaliação da influência de polimorfismos gênicos em voluntários de um estudo de bioequivalência entre duas formulações de varfarina
(Universidade Federal de Minas GeraisBrasilICB - INSTITUTO DE CIÊNCIAS BIOLOGICASPrograma de Pós-Graduação em Inovação Tecnológica e Propriedade IntelectualUFMG, 2012-02-10)
The standard single dose 2x2 crossover bioequivalence study is routinely used to determine the interchangeability of reference drugs and generic products. It’s also known that individual variability of participating ...
VKORC1 V66M mutation in African Brazilian patients resistant to oral anticoagulant therapy
(Pergamon-elsevier Science LtdOxfordInglaterra, 2010)
CYP2C9 and VKORC1 Polymorphisms Are Differently Distributed in the Brazilian Population According to Self-Declared Ethnicity or Genetic Ancestry
(MARY ANN LIEBERT INCNEW ROCHELLE, 2012)
Background: Warfarin-dosing pharmacogenetic algorithms have presented different performances across ethnicities, and the impact in admixed populations is not fully known. Aims: To evaluate the CYP2C9 and VKORC1 polymorphisms ...
Avaliação de polimorfismos genéticos e a dose terapêutica da varfarina em pacientes com trombose: um estudo de coorte
(Universidade Federal de Minas GeraisUFMG, 2014-10-31)
The treatment of thromboembolic diseases aims to maintain a stable and personalized anticoagulation, for which the warfarin anticoagulant is the treatment of choice. The influence of several factors on the action of warfarin ...