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Genome cyclization as strategy for flavivirus RNA replication
(Elsevier Science, 2008-09)
Long-range and local RNA-RNA contacts in viral RNA genomes result in tertiary structures that modulate the function of enhancers, promoters, and silencers during translation, RNA replication, and encapsidation. In the case ...
Exploring RNA Virus Replication in Xenopus Oocytes
(Humana Press, 2006)
Microinjection of poliovirus RNA in Xenopus oocytes initiates a complete and authentic viral replication cycle that yields newly synthesized infectious virus. This system can be used to study the molecular mechanism of the ...
F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis
(American Society For Microbiology, 2011-06)
The mechanism by which viral RNA-dependent RNA polymerases (RdRp) specifically amplify viral genomes is still unclear. In the case of flaviviruses, a model has been proposed that involves the recognition of an RNA element ...
Dynamic RNA structures in the dengue virus genome
(Landes Bioscience, 2011)
Dengue virus is an important human pathogen that belongs to the Flaviviridae family. The viral genome is a single molecule of RNA of positive polarity that plays multiple roles during the viral life cycle. Besides encoding ...
Functional RNA Elements in the Dengue Virus Genome
(Molecular Diversity Preservation International, 2011-09-15)
Dengue virus (DENV) genome amplification is a process that involves the viral RNA, cellular and viral proteins, and a complex architecture of cellular membranes. The viral RNA is not a passive template during this process; ...
Flaviviruses
(Springer, 2009)
Flavivirus genome amplification is a complex process that involves the viral RNA, cellular and viral proteins, and a sophisticated architecture of cellular membranes induced by viral infection. The viral RNA is not just a ...
A balance between circular and linear forms of the dengue virus genome is crucial for viral replication
(Cold Spring Harbor Laboratory Press, 2010-12)
The plasticity of viral plus strand RNA genomes is fundamental for the multiple functions of these molecules. Local and long-range RNA - RNA interactions provide the scaffold for interacting proteins of the translation, ...
Molecular characterization of IPNV RNA replication intermediates during the viral infective cycle
(2009)
Infectious Pancreatic Necrosis Virus (IPNV) is a bisegmented, double-stranded RNA virus, which belongs to the Birnaviridae family. In the current study, we have analyzed the RNA replication intermediates (RI) purified ...
Who Regulates Whom? An Overview of RNA Granules and Viral Infections
(MDPI AG, 2016)
After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the ...
Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicase
(Public Library Of Science, 2012-04)
The flavivirus nonstructural protein 3 (NS3) bears multiple enzymatic activities and represents an attractive target for antiviral intervention. NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, ...