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α,25(OH)2D3 Promotes oxidative stress in endothelial cells transformed by vGPCR
(Tech Science Press, 2020)
The infectious cause of Kaposi’s sarcoma (KS) neoplasm is KS-associated Herpesvirus (KSHV or human herpesvirus 8). Furthermore, virally G Protein-coupled Receptor (vGPCR) is one of the molecules from the lytic phase able ...
Antineoplastic effect of 1α,25(OH)2D3 in spheroids from endothelial cells transformed by Kaposi’s sarcoma-associated herpesvirus G protein coupled receptor
(Elsevier Science, 2019-02)
The Kaposi´s sarcoma-associated herpesvirus G protein-coupled receptor (KSHV/vGPCR) is a key molecule in the pathogenesis of Kaposi´s sarcoma. In endothelial cells, tumor maintenance and NF-κB activation depends on vGPCR ...
Antiproliferative effects of Bortezomib in endothelial cells transformed by viral G protein-coupled receptor associated to Kaposi's sarcoma
(Elsevier Science Inc, 2017-04)
The Kaposi's Sarcoma-associated Herpes virus G Protein-Coupled Receptor (vGPCR) is a key molecule in the pathogenesis of Kaposi Sarcoma. We have previously demonstrated that the proteasome inhibitor Bortezomib inhibits ...
KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi's sarcoma
(Public Library of Science, 2020-10)
Kaposi's sarcoma-associated herpesvirus (KSHV) vGPCR is a constitutively active G protein-coupled receptor that subverts proliferative and inflammatory signaling pathways to induce cell transformation in Kaposi's sarcoma. ...
α,25(OH)2D3 promotes oxidative stress in endothelial cells transformed by vGPCR
(Tech Science Press, 2021)
The infectious cause of Kaposi’s sarcoma (KS) neoplasm is KS-associated Herpesvirus (KSHV or human herpesvirus 8). Furthermore, virally G Protein-coupled Receptor (vGPCR) is one of the molecules from the lytic phase able ...
In vitro studies revealed a downregulation of Wnt/β-catenin cascade by active vitamin D and TX 527 analog in a Kaposi's sarcoma cellular model
(Pergamon-Elsevier Science Ltd, 2020-03)
The Kaposi´s sarcoma-associated herpesvirus G-protein-coupled receptor (vGPCR) is a key molecule in the pathogenesis of Kaposi´s sarcoma. We have previously demonstrated that 1α,25(OH)2D3 or its less calcemic analogTX 527 ...
Antineoplastic effect of 1α,25(OH)2D3 in spheroids from endothelial cells transformed by Kaposi’s sarcoma-associated herpesvirus G protein coupled receptor
(Elsevier, 2019)
The Kaposi´s Sarcoma-associated Herpes virus G Protein-Coupled Receptor (vGPCR) is a key molecule in the pathogenesis of Kaposi?s sarcoma. Persistent expression and activity of vGPCR is required for NFB pathway activation ...
Estudio de la apoptosis y autofagia como parte del mecanismo antineoplásico de la vitamina D en el sarcoma de Kaposi
(2019-03-21)
El herpesvirus asociado al sarcoma de Kaposi, KSHV, es el agente etiológico del sarcoma de Kaposi. Dentro del genoma viral, el receptor viral acoplado a proteína G (vGPCR) conduce a la oncogénesis y angiogénesis; su expresión ...
The proapoptotic protein Bim is up regulated by 1α,25-dihydroxyvitamin D3 and its receptor agonist in endothelial cells and transformed by viral GPCR associated to Kaposi sarcoma
(Elsevier Science Inc, 2015-08)
We have previously shown that 1a,25-dihydroxyvitamin D3 [1a,25(OH)2D3] and its less calcemic analogTX 527 induce apoptosis via caspase-3 activation in endothelial cells (SVEC) and endothelial cells transformedby the viral ...