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Valinomycin as a potential antiviral agent against coronaviruses: a review
Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), ...
Free energies underlying ion binding and transport in protein channels: Free energy perturbation simulations of ion binding and selectivity for valinomycin
(Royal Soc Chemistry, 1991)
As a step to increasing the reliability of the calculation of free energies underlying ion binding and transport in protein channels, free energy perturbation simulations have been performed for the binding of alkali-metal ...
Membrane hyperpolarization abolishes calcium oscillations that prevent induced acrosomal exocytosis in human sperm
(Federation of American Societies for Experimental Biology, 2021)
Sperm capacitation is essential to gain fertilizing capacity. During this process, a series of biochemical and physiological modifications occur that allow sperm to undergo acrosomal exocytosis (AE). At the molecular level, ...
Free energy perturbation simulations of cation binding to valinomycin
(Kluwer Academic Publishers, 1992)
Experimental values of the free energies of cation binding to the cyclic depsipeptide molecule, valinomycin, obtained from Pedersen-type salt extraction measurements, provide data against which it is possible to test the ...
VALINOMYCIN INHIBITION OF THE ELECTRICAL-ACTIVITY OF MOUSE PANCREATIC BETA-CELLS
(Assoc Bras Divulg CientificaSao PauloBrasil, 1983)
[Ca2+]ioscillations in human sperm are triggered in the flagellum by membrane potential-sensitive activity of CatSper
(Oxford University Press, 2020-12)
STUDY QUESTION: How are progesterone (P4)-induced repetitive intracellular Ca2+ concentration ([Ca2+]i) signals (oscillations) in human sperm generated? SUMMARY ANSWER: P4-induced [Ca2+]i oscillations are generated in the ...
Produção, isolamento e identificação de metabólito com atividade citotóxica de cultura de Streptomyces carpaticus
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Engenharia Química - PPGEQ, 2011-09-21)
This study addresses the production, isolation and identification of the substance present in culture broth of Streptomyces carpaticus which showed high biological activity against human tumor cell lines HL-60 (promyelocytic ...
Ion-selective properties of a small ionophore in methanol studied by free energy perturbation simulations
(1992)
The ion-selective properties of the cyclic depsipeptide molecule valinomycin in methanol are studied by free energy perturbation molecular dynamics simulations. The dependence of the alkali cation selectivity on the dipole ...