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The anti-cancer agent nemorosone is a new potent protonophoric mitochondrial uncoupler
(ELSEVIER SCI LTD, 2011)
Nemorosone, a natural-occurring polycyclic polyprenylated acylphloroglucinol, has received increasing attention due to its strong in vitro anti-cancer action. Here, we have demonstrated the toxic effect of nemorosone (1-25 ...
Respiration, oxidative phosphorylation, and uncoupling protein in Candida albicans
(Associação Brasileira de Divulgação Científica, 2004)
Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines
(Elsevier, 2020)
Introduction: Colorectal cancer (CRC) is a critical health issue worldwide. The high rate of liver and lung metastasis associated with CRC creates a significant barrier to effective and efficient therapy. Tumour cells, ...
Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation
(Academic Press Elsevier Science, 2016)
Mitochondria participate in several distinctiveness of cancer cell, being a promising target for the design of anti-cancer compounds. Previously, we described that ortho-carbonyl hydroquinone scaffold 14 inhibits the complex ...
Efeitos de lantadenos sobre a bioenergética em mitocôndrias isoladas de fígado de rato
(Universidade Estadual Paulista (UNESP), 2014)