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Computational chemical analysis of unconjugated bilirubin anions and insights into pKa values clarification
(American Institute of Physics, 2013-11)
The pKa, the negative logarithm of the acid dissociation equilibrium constant, of the carboxylic acid groups of unconjugated bilirubin in water is a discussed issue because there are quite different experimental values ...
Unconjugated bilirubin inhibits C1 esterase activity
(Pergamon-Elsevier Science Ltd, 2009-06)
Objective: To evaluate if unconjugated bilirubin (UB) inhibits C1 esterase activity. Design and methods: Esterase activity was evaluated by C1-mediated hydrolysis of N-acetyl-l-tyrosine ethyl ester, and binding of UB to ...
Physiological concentrations of unconjugated bilirubin prevent oxidative stress‑induced hepatocanalicular dysfunction and cholestasis
(Springer, 2014-11)
Bilirubin is an endogenous antioxidant with cytoprotective properties, and several studies highlight its potential in the treatment of pro-oxidant diseases. We demonstrated that oxidative stress (OS), a key feature in most ...
Effect of bilirubin on toxicity induced by trifluoperazine, dibucaine and praziquantel to erythrocytes
(Pergamon-elsevier Science LtdOxfordInglaterra, 2001)
Loci From a Genome-Wide Analysis of Bilirubin Levels Are Associated With Gallstone Risk and Composition
(W B SAUNDERS CO-ELSEVIER INC, 2010)
BACKGROUND & AIMS: Genome-wide association studies have mapped loci that are associated with serum levels of bilirubin. Bilirubin is a major component of gallstones so we investigated whether these variants predict gallstone ...
Role of brain cytochrome P450 mono‑oxygenases in bilirubin oxidation‑specific induction and activity
(Springer, 2014-11)
In the Crigler–Najjar type I syndrome, the genetic absence of efficient hepatic glucuronidation of unconjugated bilirubin (UCB) by the uridine 5′-diphospho-glucuronosyltransferase1A1 (UGT1A1) enzyme produces the rise of ...
Kernicterus in an adult dog
(Universidade Federal do Rio Grande do Sul, 2019)
Kernicterus in an Adult Dog
(Universidade Federal do Rio Grande do Sul, 2018)