Ubiquitin, a protein widely conserved in eukaryotes, is involved in many cellular processes, including proteolysis. While sequences encoding ubiquitin-like proteins have not been identified in prokaryotic genomes sequenced ...

Protein ubiquitination leading to degradation by the proteasome is an important mechanism in regulating key cellular functions. Protein ubiquitination is carried out by a three step process involving ubiquitin (Ub) activation ...

Cell homeostasis requires precise coordination of cellular proteins function. Ubiquitination is a post-translational modification that modulates protein half-life and function and is tightly regulated by ubiquitin E3 ligases ...

Buried seedlings must grow both strongly, to push through soil to the surface, and fast, to reach the light as quickly as possible. A recent study finds that a pair of sequentially acting E3 ubiquitin ligases balances these ...

The modification of proteins with ubiquitin is a critical event that determines the fate of many proteins in the cell. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ...

The ubiquitin-proteasome system governs the half-life of most cellular proteins. Calorie restriction (CR) extends the maximum life span of a variety of species and prevents oxidized protein accumulation. We studied the ...