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Aerobic Exercise Training Induces the Mitonuclear Imbalance and UPRmt in the Skeletal Muscle of Aged Mice
(Oxford Univ Press Inc, 2020-12-01)
The impairment of the mitochondrial functions is a hallmark of aging. During aging, there is a downregulation of two mechanisms strictly associated with mitochondrial integrity, including the mitonuclear imbalance (eg, ...
High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice
(Springer, 2020-07-31)
The impairment of mitochondrial metabolism is a hallmark of aging. Mitonuclear imbalance and the mitochondrial unfolded protein response (UPRmt) are two conserved mitochondrial mechanisms that play critical roles in ensuring ...
Estudio de la respuesta mitocondrial a proteínas mal-plegadas (UPRmt) en el músculo esquelético de ratones alimentados con dieta alta en grasa
(Universidad de Chile, 2022)
La obesidad, es definida como la “acumulación anormal y excesiva de grasa” de acuerdo con la
organización mundial para la salud (OMS). El músculo esquelético es el órgano encargado de generar la
fuerza y el movimiento, ...
Impact of mitophagy and mitochondrial unfolded protein response as new adaptive mechanisms underlying old pathologies: sarcopenia and non-alcoholic fatty liver disease
(MDPI, 2020)
Mitochondria are the first-line defense of the cell in the presence of stressing processes that can induce mitochondrial dysfunction. Under these conditions, the activation of two axes is accomplished, namely, (i) the ...
O impacto da mutação no gene LIPL-5 sobre a expressão da enzima Lipase-like 4 e resposta ao estresse em Caenorhabditis elegans
(Universidade Federal de São Paulo (UNIFESP), 2021)
Introduction: Mitochondria are important organelles for the organism, as they are involved in several physiological processes crucial to the maintenance of homeostasis. In a study conducted previously by our group, it was ...
The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging
(Frontiers Media S.A., 2020-09)
Aging is the time-dependent functional decline that increases the vulnerability to different forms of stress, constituting the major risk factor for the development of neurodegenerative diseases. Dysfunctional mitochondria ...