Buscar
Mostrando ítems 1-6 de 6
Drug Binding to Plasma Proteins
(Springer Nature Switzerland AG, 2021)
After absorption, most drugs will distribute heterogeneouslyacross tissues and organs, with the total drug concentration in plasmagenerally not being representative of the total concentration in other tissues.The main ...
Brain-to-Plasma Concentration Ratio and Unbound Partition Coefficient
(Springer Nature Switzerland AG, 2021)
The brain-to-plasma concentration ratio (or totalbrain-to-plasma ratio, or simply, brain-to-plasma ratio, Kp, also referred toas B/P ratio or BB) is, as suggested by the name, the ratio between the total(bound and unbound) ...
Combined Microdialysis-Tumor Homogenate Method for the Study of the Steady State Compartmental Distribution of a Hydrophobic Anticancer Drug in Patient-Derived Xenografts
(Springer, 2014-03)
PURPOSE: To develop a reproducible microdialysis-tumor homogenate method for the study of the intratumor distribution of a highly hydrophobic anticancer drug (SN-38; 7-ethyl-10-hydroxycamptothecin) in neuroblastoma ...
Enantioselective inhibition of human CYP2C19 by the chiral pesticide ethofumesate: Prediction of pesticide-drug interactions in humans
(2021-08-25)
Ethofumesate is a chiral herbicide that may display enantioselective behavior in humans. For this reason, the enantioselective potential of ethofumesate and its main metabolite ethofumesate-2-hydroxy to cause pesticide-drug ...
Experiencia del uso de ácido valproico intravenoso en estatus epiléptico en la fundación Cardio Infantil – I.C. de Bogotá
(Universidad del RosarioEspecialización en NeurologíaEscuela de Medicina y Ciencias de la Salud, 2007)
Estudio farmacocinético de quercetina-3-O-rutinósido a partir de un extracto estandarizado de cálices de Physalis peruviana en dos modelos animales
(Bogotá - Ciencias - Doctorado en Ciencias FarmacéuticasDepartamento de FarmaciaUniversidad Nacional de Colombia - Sede Bogotá, 2020-12-04)
Physalis peruviana es una planta de la familia Solanaceae con propiedades medicinales. Un extracto hidroalcohólico de cálices de P. peruviana presentó actividad antiinflamatoria e hipoglicemiante. El objetivo de esta ...