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Blockade of ERK1/2 activation with U0126 or PEP7 reduces sodium appetite and angiotensin II-induced pressor responses in spontaneously hypertensive rats
(2021-02-01)
Spontaneously hypertensive rats (SHRs) have increased daily or induced sodium intake compared to normotensive rats. In normotensive rats, angiotensin II (ANG II)-induced sodium intake is blocked by the inactivation of ...
Role of the ERK1/2 signaling pathway in the replication of junín and tacaribe viruses
(MDPI, 2018-04)
We have previously shown that the infection of cell cultures with the arenaviruses Junín (JUNV), Tacaribe (TCRV), and Pichindé promotes the phosphorylation of mitogen-activated protein kinases (MAPKs) extracellular ...
Participación de las vías de señalización celular dependientes de proteínas quinasas activadas por mitógenos Raf/MEK/ERK y p38 en la multiplicación del virus JunínInvolvement of mitogen-activated protein kinase - dependent signaling pathways Raf/MEK/ERK and p38 in Junín virus multiplication
(2019-03-12)
El virus Junín (JUNV), miembro de la familia Arenaviridae, es el agente causal de la fiebre hemorrágica argentina, enfermedad endemo-epidémica que afecta una amplia zona central de la República Argentina y para la cual, ...
Sequence dependent exposure of mammary carcinoma cells to Taxotere® and the MEK1/2 inhibitor U0126 causes enhanced cell killing in vitro
(Taylor & Francis, 2003-11)
Taxol (paclitaxel) and Taxotere (docetaxel) are considered as two of the most important anticancer chemotherapy drugs. The cytotoxic action of these drugs has been linked to their ability to inhibit microtubule depolymerization, ...
Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway
(Wiley Blackwell Publishing, Inc, 2006-07-26)
Identifying the trophic factors for retina photoreceptors and the intracellular pathways activated to promote cell survival is crucial for treating retina neurodegenerative diseases. Docosahexaenoic acid (DHA), the major ...
Estabelecimento e caracterização de um modelo in vivo e in vitro de mixoma odontogênico
(Universidade Federal de Minas GeraisBrasilMEDICINA - FACULDADE DE MEDICINAPrograma de Pós-Graduação em Medicina MolecularUFMG, 2021-05-03)
Odontogenic myxoma (OM) is a rare intraosseous neoplasm. Despite being benign, OM has an aggressive behavior and is locally infiltrative, which can cause facial deformities and impact patient’s quality of life. In addition, ...
Angiotensin II Signaling in Human Preadipose Cells: Participation of ERK1,2-Dependent Modulation of Akt
(2013-10)
The renin-angiotensin system expressed in adipose tissue has been implicated in the modulation of adipocyte formation,
glucose metabolism, triglyceride accumulation, lipolysis, and the onset of the adverse metabolic ...