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c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer's disease
(Wiley, 2023)
BackgroundGrowing evidence suggests that the non-receptor tyrosine kinase, c-Abl, plays a significant role in the pathogenesis of Alzheimer's disease (AD). Here, we analyzed the effect of c-Abl on the cognitive performance ...
c-Abl tyrosine kinase down-regulation as target for memory improvement in Alzheimer's disease
(2023)
BackgroundGrowing evidence suggests that the non-receptor tyrosine kinase, c-Abl, plays a significant role in the pathogenesis of Alzheimer's disease (AD). Here, we analyzed the effect of c-Abl on the cognitive performance ...
C-Abl tyrosine kinase inhibitory compound embodiments and methods of making and using the same.
(2023)
Disclosed herein are embodiments of a compound that inhibits c-Abl tyrosine kinase (also referred to herein as “c-Abl”). The compound embodiments described herein are novel c-Abl inhibitors that can bind to c-Abl at an ...
New mutation L324M in the ABL1 kinase domain: does it confer high resistance to second-generation inhibitors?
(Taylor & Francis Ltd, 2014-03)
In chronic myeloid leukemia (CML) the presence of mutations in the tyrosine kinase domain (TK) of the normalABL1 gene is the most common cause of loss of response to treatment. Detection of these mutations is an important ...
c-Abl activates RIPK3 signaling in Gaucher disease
(2021)
Gaucher disease (GD) is caused by homozygous mutations in the GBA1 gene, which encodes the lysosomal β-glucosidase (GBA) enzyme. GD affects several organs and tissues, including the brain in certain variants of the disease. ...
Activation of the neuronal c-abl tyrosine kinase by amyloid-beta-peptide and reactive oxygen species
(BLACKWELL SCIENCE, 2004)
C-abl tyrosine kinase modulates tau pathology and cdk5 phosphorylation in ad transgenic mice
(ELSEVIER SCIENCE INC, 2011)
C-abl tyrosine kinase signaling: a new player in ad taupathology
(BENTHAM SCIENCE PUBLISHERS, 2011)
AMYLOID-B-PEPTIDE ACTIVATES THE NEURONAL C-ABL TYROSINE KINASE/ P73 SIGNALING TRANSDUCTION PATHWAY
(NOVA SCIENCE PUBLISHERS, INC., 2008)