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Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasone
Background: Quinones are reactive to proteins containing cysteine residues and the main protease
in Covid-19 contains an active site that includes Cys145. Embelin, a quinone natural product, is
known to have antiviral ...
Boron in drug design: Recent advances in the development of new therapeutic agents
(Elsevier B.V., 2019-10-01)
Advances in the field of boron chemistry have expanded the application of this element in Medicinal Chemistry. Boron-containing compounds represent a new class for medicinal chemists to use in their drug designs. Bortezomib ...
Design of novel iron compounds as potential therapeutic agents against tuberculosis
(Elsevier B.V., 2010-11-01)
In the search for new therapeutic tools against tuberculosis two novel iron complexes, [Fe(L-H)3], with 3-aminoquinoxaline-2-carbonitrile N(1),N(4)-dioxide derivatives (L) as ligands, were synthesized, characterized by a ...
A cross-over study on the effect of various therapeutic approaches to morning breath odour
(Blackwell PublishingOxfordInglaterra, 2006)
Therapeutic properties and structural characterization of steroidal saponins: a review
(Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos. Centro de Inovação em Biodiversidade e Saúde, 2021)
Design of novel iron compounds as potential therapeutic agents against tuberculosis
(ElsevierNew York, 2010-11)
In the search for new therapeutic tools against tuberculosis two novel iron complexes, [Fe(L–H)3], with 3-
aminoquinoxaline-2-carbonitrile N1,N4-dioxide derivatives (L) as ligands, were synthesized, characterized by
a ...
Design of novel iron compounds as potential therapeutic agents against tuberculosis
(Elsevier B.V., 2010-11-01)
In the search for new therapeutic tools against tuberculosis two novel iron complexes, [Fe(L-H)3], with 3-aminoquinoxaline-2-carbonitrile N(1),N(4)-dioxide derivatives (L) as ligands, were synthesized, characterized by a ...
Endophytic fungi from Passiflora incarnata: an antioxidant compound source
(2020-01-01)
Endophytes are considered one of the most important microbial resources for obtaining biomolecules of therapeutic use. Passiflora incarnata, widely employed by the pharmaceutical industry, shows therapeutic effects on ...
Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target?
(Elsevier Gmbh, 2014-07)
BACKGROUND: Chagas disease or American Trypanosomiasis is caused by the flagellated protozoan parasite Trypanosoma cruzi (T. cruzi) and is recognized by the WHO as one of the world's 17 neglected tropical diseases. Only ...