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Stimulation of Variant Forms of the Mitochondrial DNA Helicase Twinkle by the Mitochondrial Single-Stranded DNA-Binding Protein
(2021-01-01)
Defects in mitochondrial DNA (mtDNA) maintenance may lead to disturbances in mitochondrial homeostasis and energy production in eukaryotic cells, causing diseases. During mtDNA replication, the mitochondrial single-stranded ...
O papel da helicase mitocondrial Twinkle em tecidos muscular e nervoso de Drosophila melanogaster
(Universidade Estadual Paulista (Unesp), 2022-11-10)
Mutações no gene humano TWNK, responsável por codificar a helicase mitocondrial Twinkle, frequentemente causam doenças mitocondriais que afetam o sistema neurolocomotor de pacientes. No caso da Oftalmoplegia Progressiva ...
Efeitos da expressão da oxidase alternativa em mutantes da helicase mitocondrial de Drosophila melanogaster
(Universidade Estadual Paulista (Unesp), 2017-07-25)
Mutações no gene nuclear humano C10orf2, que codifica a helicase mitocondrial Twinkle, são apontadas como causa da forma autossômica dominante da doença Oftalmoplegia Progressiva Externa (adPEO), associada a múltiplas ...
Roles of the mitochondrial replisome in mitochondrial DNA deletion formation
(Soc Brasil Genetica, 2020-01-01)
Mitochondrial DNA (mtDNA) deletions are a common cause of human mitochondrial diseases. Mutations in the genes encoding components of the mitochondrial replisome, such as DNA polymerase gamma (Pol gamma) and the mtDNA ...
The confluence of innovation in therapeutics and regulation: recent cmc considerations
The field of human therapeutics has expanded tremendously from small molecules to complex
biological modalities, and this trend has accelerated in the last two decades with a greater diversity in the
types and applications ...
Original research by young twinkle students (ORBYTS): Ephemeris refinement of transiting exoplanets
(Oxford University Press, 2021-07)
We report follow-up observations of transiting exoplanets that have either large uncertainties (>10 min) in their transit times or have not been observed for over 3 yr. A fully robotic ground-based telescope network, ...
Elementos del Diseño Gráfico incorporados en la serie animada infantil Twinkle
(Universidad Santo TomásPregrado Diseño GráficoFacultad de Diseño Gráfico, 2021-10-08)
From the emphasis on animation to the realization of the internship at Insert Coin and the knowledge acquired throughout the
and the knowledge acquired throughout the career, the aim is to understand and understand more ...
Philosophy, education and the future
(2015-10)
Human beings express themselves through words. And
these words, being time, seek their connection to freedom
or are irreversibly sentenced to oblivion. But not all
move towards freedom or oblivion, because their rhythm ...
Spatiotemporal Pattern Formation in the Oscillatory Electro-Oxidation of Sulfide on a Platinum Disk
(AMER CHEMICAL SOC, 2011)
Spatiotemporal pattern formation in the electrocatalytic oxidation of sulfide on a platinum disk is investigated using electrochemical methods and a charge-coupled device (CCD) camera simultaneously. The system is characterized ...