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HNSCC subverts PBMCs to secrete soluble products that promote tumor cell proliferation
(Impact Journals Llc, 2017-09-05)
The immune system detects shifts from homeostasis and eliminates altered cells. However, neoplastic cells can modulate the host response to escape immunosurveillance thereby allowing tumor progression. Head and neck squamous ...
Elucidating tumor immunosurveillance and immunoediting: A comprehensive reviewElucidando a imunovigilância e imunoedição tumoral: uma revisão abrangente
(2021-01-01)
The action of the immune system against neoplastic diseases has become one of the main sources of research. The biological pathways of this system are known to contribute in limiting the progression and elimination of the ...
Mind the gaps in tumor immunity: impact of connexin mediated intercellular connections
(Frontiers media SA, 2017)
Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-formed plasma membrane channels that allow for the passage of small molecules between adjacent cells, and are involved in several ...
Tumor immune escape mechanisms that operate during metastasis
(Bentham Science Publishers, 2011-04)
Immune cells actively influence, among other factors, each step of tumor development determining the chance of a cancer cell to survive in a threaten microenvironment. Antitumor immune-mediated mechanisms are activated as ...
Genetic and modifying factors that determine the risk of brain tumors
(2011-03-29)
Some modifying factors may determine the risk of brain tumors. Until now, it could not be attempted to identify people at risk and also to improve significantly disease progression. Current therapy consists of surgical ...
Genetic and modifying factors that determine the risk of brain tumors
(2011-03-29)
Some modifying factors may determine the risk of brain tumors. Until now, it could not be attempted to identify people at risk and also to improve significantly disease progression. Current therapy consists of surgical ...
Naked DNA immunization as an approach to target the generic tumor antigen survivin induces humoral and cellular immune responses in mice
(Elsevier GmbH, 2006)
Survivin, a 16.5 kDa tumor associated antigen, is the smallest member of the inhibitor of apoptosis family that is abundantly expressed during development but essentially absent in normal adult tissues. Interestingly, ...
Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: a potential mechanism of tumor-immune privilege
(Cell Press, 2004-03)
Despite the existence of tumor-specific immune cells, most tumors have devised strategies to avoid immune attack. We demonstrate here that galectin-1 (Gal-1), a negative regulator of T cell activation and survival, plays ...