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Divalent cation hinder the solubilization of a tubulin kinase activity from Trypanosoma cruzi epimastigotes
(Sociedad de Biología de Chile, 2003)
Inhibition of Tubulin Self-Assembly and Tubulin-Colchicine GTPase Activity by Guanosine 5’-γ-Fluorotriphosphate)
(1987)
The inhibitory effects of guanosine 5'-(ᵧ-fluorotriphosphate) [GTP(ᵧF)] on both the polymerization and the colchicine-dependent GTPase activity of calf brain tubulin have been studied. The results demonstrate that this ...
Structural and Chemical Basis for Anticancer Activity of a Series of beta-Tubulin Ligands: Molecular Modeling and 3D QSAR Studies
(Soc Brasileira QuimicaSao PauloBrasil, 2009)
Effects of kinesin-5 inhibition on dendritic architecture and microtubule organization
(Amer Soc Cell
Biology, 2015)
ABSTRACT Kinesin-5 is a slow homotetrameric motor protein best known for its essential role in the mitotic spindle, where it limits the rate at which faster motors can move microtubules. In neurons, experimental suppression ...
Aminochrome Induces Disruption of Actin, Alpha-, and Beta-Tubulin Cytoskeleton Networks in Substantia-Nigra-Derived Cell Line
(SPRINGER, 2010-01-20)
Abstract In previous studies, we observed that cells
treated with aminochrome obtained by oxidizing dopamine
with oxidizing agents dramatically changed cell morphology,
thus posing the question if such morphological
changes ...
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors
(Elsevier MassonIssy les Moulineaux, 2013-05)
Based on classical colchicine site ligands and a computational model of the colchicine binding site on beta tubulin, two classes of chalcone derivatives were designed, synthesized and evaluated for inhibition of tubulin ...
Investigação de moléculas híbridas para o tratamento anticâncer
(Universidade Federal de São CarlosUFSCarCâmpus São CarlosBiotecnologia - Biotec, 2022-07-06)
Cancer is the attribution given to the uncontrolled growth and proliferation of abnormal cells capable of invading and destroying the adjacent tissue. According to the World Health Organization (WHO), the global growth in ...