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Estabelecimento do cariótipo molecular e associações sintênicas entre tripanossomas de morcegos do clado Trypanosoma cruzi
(Universidade Federal de São Paulo (UNIFESP), 2017-05-30)
The genus Trypanosoma comprises hemoflagellate parasites generally transmitted to vertebrate host by hematophagous arthropods. The clade Schizotrypanum (Trypanosoma cruzi and T. cruzi-like) includes pathogenic and ...
Role of TcPARP during the metacyclogenesis of Trypanosoma cruzi
(The Australian Society for Parasitology, 2020)
Poly(ADP-ribosyl)ation is a post-translational modification catalyzed by poly(ADP- ribose)polymerases (PARPs). As a reversible modification, it is regulated by a delicate balance ofsynthesis and degradation, and is involved ...
Overexpression of Trypanosoma cruzi High Mobility Group B protein (TcHMGB) alters the nuclear structure, impairs cytokinesis and reduces the parasite infectivity
(Nature Publishing Group, 2019-01)
Kinetoplastid parasites, included Trypanosoma cruzi, the causal agent of Chagas disease, present a unique genome organization and gene expression. Although they control gene expression mainly posttranscriptionally, chromatin ...
Trypanosomatid Pin1-type Peptidyl-Prolyl Isomerase is Cytosolic and Not Essential for Cell Proliferation
(Wiley, 2012-12-03)
Pin1-type peptidyl-prolyl cis/trans isomerases (PPIases) isomerise the peptide bond of specific phosphorylated (Ser/Thr)-Pro residues, regulating various cellular events. Previously, we reported a Pin1-type PPIase in ...
Functional characterization of TcCYC2 cyclin from Trypanosoma cruzi
(Academic Press Inc Elsevier Science, 2012-06)
In eukaryotes, an oscillating network of protein kinase activities drives the order and timing of the cell cycle progression. Complexes formed by cyclins associated to cyclin-dependent kinases (CDKs) are the central ...
Elucidating diversity in the class composition of the minicircle hypervariable region of Trypanosoma cruzi: New perspectives on typing and kDNA inheritance
(Public Library of Science, 2019)
Background Trypanosoma cruzi, the protozoan causative of Chagas disease, is classified into six main Discrete Typing Units (DTUs): TcI-TcVI. This parasite has around 105 copies of the minicircle hypervariable region (mHVR) ...
Efecto de los extractos de plantas medicinales en los cultivos de Trypansoma cruzi, causante de la tripanosomiasis americana
(Universidad Autónoma Metropolitana (México). Unidad Azcapotzalco. División de Ciencias Básicas e Ingeniería., 2015)
La enfermedad de Chagas es una enfermedad parasitaria tropical, generalmente crónica, causada por el protozoo hemoflagelado Trypanosoma cruzi. Se extiende desde el Sur de EUA hasta Sudamérica. Durante el desarrollo de la ...
The control of Latin American trypanosomiasis
(Sociedade Brasileira de Medicina Tropical - SBMT, 1997)
The author presents his personal point of view on the present situation of Chagas' disease control in Latin America countries. He compares the situation with African trypanosomiasis. He comments on the existence of cases ...
Aim for the readers! Bromodomains as new targets against Chagas` disease
(Bentham Science Publishers, 2018-10)
Bromodomains recognize and bind acetyl-lysine residues present in histone and non-histone proteins in a specific manner. Inthe last decade they have raised as attractive target for drug discovery because the miss-regulation ...
Associação da expressão do fator de necrose tumoral α (TNF-α) e seus receptores na infecção de células placentárias humanas por formas tripomastigotas de Trypanosoma cruzi
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE PARASITOLOGIAPrograma de Pós-Graduação em ParasitologiaUFMG, 2022-09-23)
Chagas disease is a neglected tropical disease, caused by the protozoan Trypansoma cruzi and
endemic in Latin America. The modes of transmission include vectorial, through blood
transfusion, oral or congenital. Congenital ...