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Evaluation of proline analogs as trypanocidal agents through the inhibition of a Trypanosoma cruzi proline transporter
(Elsevier Science, 2017-08)
Background: Trypanosoma cruzi, the etiological agent of Chagas disease, uses proline as its main carbon source, essential for parasite growth and stage differentiation in epimastigotes and amastigotes. Since proline is ...
Facing Chagas' Disease: Trypanocidal Properties of New Coumarin-chalcone Scaffolds
(2016)
With the aim of finding new chemical entities based on coumarin and chalcone scaffolds, new hybrid compounds 2-5 were designed and synthesized. The trypanocidal activity of these compounds was tested against the epimastigote, ...
Absolute configuration and selective trypanocidal activity of gaudichaudianic acid enantiomers
(The American Chemical Society and American Society of Pharmacognosy, 2017)
Trypanocidal structure-activity relationship for cis- and trans-methylpluviatolide
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
The trypanocidal activity of racemic mixtures of cis- and trans-methylpluviatolides was evaluated in vitro against trypomastigote forms of two strains of Trypanosoma cruzi, and in the enzymatic assay of T. cruzi gGAPDH. ...
Characterization and trypanocidal activity of a β-lapachone-containing drug carrier
(Public Library of Science, 2021)
Natural and synthetic naphthoquinones active against Trypanosoma cruzi: An initial step towards new drugs for chagas disease
(2011)
Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and benznidazole, are toxic and present severe side ...
Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi
(Sociedade Brasileira de Farmacognosia, 2012)
Chagas disease is one of the main public health problems in Latin America. Since the available treatments for this disease are not effective in providing cure, the screening of potential antiprotozoal agents is essential, ...
Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi
(Sociedade Brasileira de Farmacognosia, 2012-06-01)
Chagas disease is one of the main public health problems in Latin America. Since the available treatments for this disease are not effective in providing cure, the screening of potential antiprotozoal agents is essential, ...
Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi
(Sociedade Brasileira de Farmacognosia, 2012-06-01)
Chagas disease is one of the main public health problems in Latin America. Since the available treatments for this disease are not effective in providing cure, the screening of potential antiprotozoal agents is essential, ...