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Tricyclic antidepressants inhibit homomeric Cys-loop receptors by acting at different conformational states
(Elsevier Science, 2008-04)
Tricyclic antidepressants not only inhibit monoamine reuptake but also modulate Cys-loop receptors. However, it is not understood how this modulation is involved in their therapeutic effects. We analyzed the mechanisms of ...
Direct comparison of tricyclic and serotonin-reuptake inhibitor antidepressants in randomized head-To-head trials in acute major depression: Systematic review and meta-Analysis
(Sage Publications, 2017)
BACKGROUND:
A comparison across trials conducted over several decades suggested superior efficacy of tricyclic antidepressants (TCAs) over selective serotonin-reuptake inhibitors (SSRIs). However, this outcome may reflect ...
Direct comparison of tricyclic and serotonin-reuptake inhibitor antidepressants in randomized head-To-head trials in acute major depression: Systematic review and meta-Analysis
(Sage Publications, 2017)
BACKGROUND:
A comparison across trials conducted over several decades suggested superior efficacy of tricyclic antidepressants (TCAs) over selective serotonin-reuptake inhibitors (SSRIs). However, this outcome may reflect ...
Antidepressant responses in direct comparisons of melancholic and non-melancholic depression
(2020)
Background: Efforts to develop less heterogeneous, more clinically useful diagnostic categories for depressive disorders include renewed interest in the
concept of melancholia (Mel). However, clinical or biological ...
Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants
(Pergamon-Elsevier Science Ltd, 2003-12)
In addition to their well known actions on monoamine reuptake, tricyclic antidepressants have been shown to modulate ligand-gated ion channels (LGICs). Since the muscle nicotinic acetylcholine receptor (AChR) has been the ...
The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha(1B)-adrenoceptors
(Pergamon-Elsevier B.V. Ltd, 2010-07-01)
Although it is long known that the tricyclic antidepressants amitriptyline, nortriptyline and imipramine inhibit the noradrenaline transporter and alpha(1)-adrenoceptors with similar affinities, which may lead to self-cancelling ...
The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha(1B)-adrenoceptors
(Pergamon-Elsevier B.V. Ltd, 2010-07-01)
Although it is long known that the tricyclic antidepressants amitriptyline, nortriptyline and imipramine inhibit the noradrenaline transporter and alpha(1)-adrenoceptors with similar affinities, which may lead to self-cancelling ...
The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha(1B)-adrenoceptors
(Pergamon-Elsevier B.V. Ltd, 2014)
Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders
(2003-07-01)
Temporomandibular disorder (TMD) is characterized by a combination of symptoms affecting the temporomandibular joint and/or chewing muscles. The two most common clinical TMD symptoms are pain and dysfunction. Pain is usually ...
Clinical evaluation of amitriptyline for the control of chronic pain caused by temporomandibular joint disorders
(2003-07-01)
Temporomandibular disorder (TMD) is characterized by a combination of symptoms affecting the temporomandibular joint and/or chewing muscles. The two most common clinical TMD symptoms are pain and dysfunction. Pain is usually ...