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Determination of triclabendazole in cattle plasma as its sulphoxide and sulphone metabolites by rotating disk sorptive extraction combined with high-performance liquid chromatography and its application to pharmacokinetic studies
(Sociedad Chilena de Quimica, 2016)
In this study, a new method for determination of triclabendazole (TCB) as its main metabolites, triclabendazole sulfoxide (TCB-SO) and triclabendazole sulfone (TCB-SO2) in animal plasma was developed. TCB is widely used ...
Pharmacologic interaction between oxfendazole and triclabendazole: In vitro biotransformation and systemic exposure in sheep
(Academic Press Inc Elsevier Science, 2019-09)
The aim of the current work was to evaluate a potential pharmacokinetic interaction between the flukicide triclabendazole (TCBZ) and the broad-spectrum benzimidazole (BZD) anthelmintic oxfendazole (OFZ) in sheep. To this ...
The Differences in the Susceptibility Patterns to Triclabendazole Sulfoxide in Field Isolates of Fasciola hepatica Are Associated with Geographic, Seasonal, and Morphometric Variations
(MDPI, 2022)
Triclabendazole (TCBZ) resistance is an emerging problem in fascioliasis that is not well understood. Studies including small numbers of parasites fail to capture the complexity of susceptibility variations between and ...
Determinación de los residuos de triclabendazol en leche de vacas procedentes de dos centros de crianza de ganado destinadas a la producción de derivados lácteos en el departamento de Cajamarca, mediante HPLC-DAD
(Universidad Peruana Cayetano HerediaPE, 2021)
Perú es un país hiperendémico para la infección por Fasciola hepática. Triclabendazol (TCBZ) es la droga de elección para tremátodos hepáticos; aunque, en los últimos años se ha incrementado los casos de resistencia en ...
Determination of triclabendazole in cattle plasma as its sulphoxide and sulphone metabolites by rotating disk sorptive extraction combined with high-performance liquid chromatography and its application to pharmacokinetic studies
(2016)
In this study, a new method for determination of triclabendazole (TCB) as its main metabolites, triclabendazole sulfoxide (TCB-SO) and triclabendazole sulfone (TCB-SO2) in animal plasma was developed. TCB is widely used ...
Resistance induced changes on triclabendazole transport in Fasciola hepatica: ivermectin reversal effect
(American Society of Parasitologists, 2006-12)
Triclabendazole (TCBZ) and albendazole (ABZ) are flukicidal benzimidazole compounds extensively used in veterinary medicine. Although TCBZ has excellent activity against mature and immature stages of the liver fluke, ...
Advances on metabolism and disposition of Bbnzimidazoles anthelmintic in Fasciola hepatica: its contribution to the phenomenon of anthelmintic resistance
(Springer, 2019)
The fascioliasis is an important zoonotic disease, particularly in underdeveloped countries. In fascioliasis, the anthelmintic control has been done mainly by the use of triclabendazole (TCBZ), which is metabolized into ...