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Click chemistry decoration of amino sterols as promising strategy to developed new leishmanicidal drugs.
(Elsevier Science Inc, 2014-01)
A series of 1,2,3-triazolylsterols was prepared from pregnenolone through reductive amination and copper(I)-catalyzed azide-alkyne cycloaddition (click chemistry). The newly generated stereocenter of the key propargylamino ...