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Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome
(2011)
Background & Aims: Metabolic syndrome is secondary to obesity and characterized by dyslipidemia, insulin resistance, and hypertension. Non-alcoholic fatty liver disease is its hepatic manifestation, whose progression-limiting ...
Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome
(2011)
Background & Aims: Metabolic syndrome is secondary to obesity and characterized by dyslipidemia, insulin resistance, and hypertension. Non-alcoholic fatty liver disease is its hepatic manifestation, whose progression-limiting ...
Vasoactive intestinal peptide induces an immunosuppressant microenvironment in the maternal fetal interface of non-obese diabetic mice and improves early pregnancy outcome
(Wiley, 2014-02)
PROBLEM: Impaired pregnancy in non-obese diabetic (NOD) mice was related to limited vascular remodeling and autoimmune background. Vasoactive intestinal peptide (VIP) has anti-inflammatory and immunosuppressant effects, ...
A obesidade associada a hiperglicemia compromete a indução de tolerância oral e agrava a alergia alimentar
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIAPrograma de Pós-Graduação em Bioquímica e ImunologiaUFMG, 2021-10-07)
Obesity associated with hyperglycemia is directly correlated with intestinal barrier dysfunction and the risk for inflammatory bowel disorders. So, we decided to investigate whether the breakdown of intestinal homeostasis ...
Pulmonary Hypertension in Obese Mice Is Accompanied by a Reduction in PPAR-γ Expression in Pulmonary Artery
(2021-09-06)
Obesity and insulin resistance (IR) are well-studied risk factors for systemic cardiovascular disease, but their impact on pulmonary hypertension (PH) is not well clarified. This study aims to investigate if diet-induced ...
Increased astrocyte reactivity in the hippocampus of murine models of type I diabetes: the non-obese diabetic (NOD) and the streptozotocin-treated mice
(Elsevier Science, 2002-11)
Diabetes can be associated with cerebral dysfunction in humans and animal models of the disease. Moreover, brain anomalies and alterations of the neuroendocrine system are present in type 1 diabetes (T1D) animals, such as ...