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Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells
(The American Society of Gene & Cell Therapy, 2012-01)
The adaptive immune response to viral vectors reduces vector-mediated transgene expression from the brain. It is unknown, however, whether this loss is caused by functional downregulation of transgene expression or death ...
An update on genetically modified crops
(Pontificia Universidad Católica de Chile. Facultad de Agronomía e Ingeniería Forestal, 2008)
Atherosclerosis in aged mice over-expressing the reverse cholesterol transport genes
(Associação Brasileira de Divulgação Científica, 2005)
Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites.
(Nature Publishing Company, 2016)
Benefícios e riscos do consumo de alimentos transgênicos: revisão crítica da literaturaBenefits and risks of transgenic food consumption: a critical review of literature
(DFAL - Departamento de Farmácia – Lagarto - PresencialUFS, 2018)
Particulate mediators of the bystander effect linked to suicide and interferon-β transgene expression in melanoma cells
(Nature Publishing Group, 2020-03)
In the context of comparative oncology, melanoma cells derived from companion animal tumors are good models for optimizing and predicting their in vivo response to therapeutic strategies. Here, we report that human, canine, ...
Inducción de tolerancia inmunológica específica para un antígeno mediante una vacuna DNA
(2008-09-25)
RESUMEN: La terapia génica posee un gran potencial para el tratamiento de diversas enfermedades hereditarias. Este tipo de tratamiento basado en la introducción en un individuo de material genético nuevo, tiene algunos ...