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The effects of mirabegron on obesity-induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue

The Ohio State University Wexner Medical Center; Universidade Estadual Paulista (UNESP); Universidade Estadual de Campinas (UNICAMP); Metropolitan University of Santos (2021-11-01)

Mirabegron is a selective β₃-adrenergic receptors agonist, which has been recently shown to improve metabolic health in rodents and humans. In this study, we investigated the effects of 2-week mirabegron treatment on the ...

Adipose tissue inflammation and cancer cachexia: Possible role of nuclear transcription factors

Batista, M. L., Jr.; Peres, S. B.; McDonald, M. E.; Alcântara, Paulo Sérgio Martins de; Olivan, M.; Otoch, José Pinhata; Farmer, S. R.; Seelaender, Marilia Cerqueira Leite (ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDLONDON, 2012)

Cancer cachexia is a multifaceted syndrome whose aetiology is extremely complex and is directly related to poor patient prognosis and survival. Changes in lipid metabolism in cancer cachexia result in marked reduction of ...

Macrophage polarization: implications on metabolic diseases and the role of exercise

Sanches Silveira, Loreana; Mello Antunes, Barbara de Moura; Minari, André Luis Araújo [UNIFESP]; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Rosa Neto, José Cesar; Lira, Fabio Santos de (Consel Brasil Oftalmologia, 2016)

Macrophages are cells of the innate immune response that trigger inflammation resolution. The phenotype of "classically activated macrophages" (M1) has anti-tumoricidal and anti-bactericidal activities. On the other hand, ...

Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB

Illesca, Paola; Valenzuela, Rodrigo; Espinosa, Alejandra; Echeverría, Francisca; Soto-Alarcon, Sandra; Ortiz, Macarena; Videla, Luis A. (2023)

Pafr In Adipose Tissue Macrophages Is Associated With Anti-inflammatory Phenotype And Metabolic Homoeostasis

Filgueiras; LR; Koga; MM; Quaresma; PG; Ishizuka; EK; Montes; MBA; Prada; PO; Saad; MJ; Jancar; S; Rios; FJ (PORTLAND PRESS LTDLONDON, 2016)

Macrophage immunophenotype but not anti-inflammatory profile is modulated by peroxisome proliferator-activated receptor gamma (PPAR gamma) in exercised obese mice

Universidade Estadual Paulista (Unesp); Universidade de São Paulo (USP) (W W F Verlagsgesellschaft Gmbh, 2020-01-01)

Moderate aerobic training may be therapeutic for chronic low-grade inflammatory diseases due to the associated antiinflammatory response that is mediated by immune cells. The peroxisome proliferator-activated receptor gamma ...

Macrophage immunophenotype but not anti-inflammatory profile is modulated by peroxisome proliferator-activated receptor gamma (PPARγ) in exercised obese mice

Universidade Estadual Paulista (Unesp); Universidade de São Paulo (USP) (2020-01-01)

Moderate aerobic training may be therapeutic for chronic low-grade inflammatory diseases due to the associated anti-inflammatory response that is mediated by immune cells. The peroxisome proliferator-activated receptor ...

Angiotensin II and human obesity. A narrative review of the pathogenesis.: Angiotensina II y obesidad humana. Revisión narrativa de la patogénesis.

Mosquera-Sulbarán, Jesús; Ryder, Elena; Vargas, Renata; Pedreáñez, Adriana (Universidad del Zulia, 2022)

Protective effects of eicosapentaenoic acid plus hydroxytyrosol supplementation against white adipose tissue abnormalities in mice fed a high-fat diet

Illesca, Paola; Valenzuela Báez, Rodrigo; Espinosa, Alejandra; Echeverría González, Francisca; Soto Alarcón, Sandra; Campos, Cristian; Rodríguez, Alicia; Vargas, Romina; Magrone, Thea; Videla Cabrera, Luis Alaberto (MDPI, 2020)

Objective: Obesity induced by high-fat diet (HFD) elicits white adipose tissue dysfunction. In this study, we have hypothesized that the metabolic modulator eicosapentaenoic acid (EPA) combined with the antioxidant ...

Characterization of Visceral and Subcutaneous Adipose Tissue Transcriptome and Biological Pathways in Pregnant and Non-Pregnant Women: Evidence for Pregnancy-Related Regional-Specific Differences in Adipose Tissue

Mazaki-Tovi, Shali; Vaisbuch, Edi; Tarca, Adi L.; Kusanovic, Juan Pedro; Than, Nandor Gabor; Chaiworapongsa, Tinnakorn; Dong, Zhong; Hassan, Sonia S.; Romero, Roberto (Public Library Science, 2015)

Objective The purpose of this study was to compare the transcriptome of visceral and subcutaneous adipose tissues between pregnant and non-pregnant women. Study Design The transcriptome of paired visceral and ...

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