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Mostrando ítems 1-10 de 17
Role of non-coding regulatory RNA in the virulence of human pathogenic vibrios
(Frontiers Media S.A., 2017)
Effects of a glyphosate-based herbicide on the uterus of adult ovariectomized rats
(John Wiley & Sons Inc, 2017-04)
Glyphosate is the active ingredient of several herbicide formulations. Different reports suggest that glyphosate-based herbicides (GBHs) may act as endocrine disruptors. We evaluated the potential estrogenic effects of a ...
Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity
(Elsevier, 2016)
Doxorubicin (Doxo) is one of the most effective anti-neoplastic agents but its cardiotoxicity has been an important clinical limitation. The major mechanism of Doxo-induced cardiotoxicity is associated to its oxidative ...
Effects of a glyphosate-based herbicide on the uterus of adult ovariectomized rats.
(John Wiley & Sons Inc, 2017-04)
Glyphosate is the active ingredient of several herbicide formulations. Different reports suggest that glyphosate-based herbicides (GBHs) may act as endocrine disruptors. We evaluated the potential estrogenic effects of a ...
Mechanisms of Chromium VI-induced apoptosis in anterior pituitary cells
(Elsevier Ireland, 2008-12)
Hexavalent chromium (Cr (VI)) is a highly toxic metal. Exposure to Cr (VI) compounds may affect reproductive functions. Due to the importance of anterior pituitary hormones on reproductive physiology we have studied the ...
Aging whole blood transcriptome reveals candidate genes for SARS-CoV-2-related vascular and immune alterations
(2022-02-01)
Abstract: The risk of severe COVID-19 increases with age as older patients are at highest risk. Thus, there is an urgent need to identify how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with blood ...
Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity
(Elsevier Ireland, 2014-04)
ABC transporters including MRP2, MDR1 and BCRP play a major role in tissue defense. Epidemiological and experimental studies suggest a cytoprotective role of estrogens in intestine,though the mechanism remains poorly ...
Hexachlorobenzene modulates the crosstalk between the aryl hydrocarbon receptor and transforming growth factor-β1 signaling, enhancing human breast cancer cell migration and invasion
(Elsevier Ireland, 2016-07)
Given the number of women affected by breast cancer, considerable interest has been raised in understanding the relationships between environmental chemicals and disease onset. Hexachlorobenzene (HCB) is a dioxin-like ...
Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats
(Elsevier Ireland, 2017-09)
Multidrug resistance-associated protein 2 (Mrp2, ABCC2) and P-glycoprotein (P-gp, ABCB1) constitute essential components of the intestinal biochemical barrier that prevent incorporation of food contaminants, drugs or toxic ...
Bacterial Diversity Assessment In Soil Of An Active Brazilian Copper Mine Using High-throughput Sequencing Of 16s Rdna Amplicons
(Kluwer Academic Publishers, 2014)