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Mostrando ítems 1-10 de 22
Prostaglandins Isolated from the Octocoral Plexaura homomalla: In Silico and In Vitro Studies Against Different Enzymes of Cancer
(Marine Drugs, 2020-02-27)
Prostaglandin A2-AcMe (1) and Prostaglandin A2 (2) were isolated from the octocoral Plexaura homomalla and three semisynthetic derivatives (3–5) were then obtained using a reduction protocol. All compounds were identified ...
Prostaglandins Isolated from the Octocoral Plexaura homomalla: In Silico and In Vitro Studies Against Different Enzymes of CancerProstaglandinas Aisladas del Octocoral Plexaura homomalla: Estudios In Silico e In Vitro Contra Diferentes Enzimas del Cáncer
(Marine drugs, 2020)
Prostaglandin A2-AcMe (1) and Prostaglandin A2 (2) were isolated from the octocoral Plexaura homomalla and three semisynthetic derivatives (3–5) were then obtained using a reduction protocol. All compounds were identified ...
Prostaglandins Isolated from the Octocoral Plexaura homomalla: In Silico and In Vitro Studies Against Different Enzymes of CancerProstaglandinas Aisladas del Octocoral Plexaura homomalla: Estudios In Silico e In Vitro Contra Diferentes Enzimas del Cáncer
(Marine drugs, 2020)
Prostaglandin A2-AcMe (1) and Prostaglandin A2 (2) were isolated from the octocoral Plexaura homomalla and three semisynthetic derivatives (3–5) were then obtained using a reduction protocol. All compounds were identified ...
Computational studies, design and synthesis of Pd(II)-based complexes: Allosteric inhibitors of the Human Topoisomerase-IIα
(2019-10-01)
Herein, a robust docking protocol was developed by using a low-cost workflow to highlight the modulation at ATPase domain from Human Topoisomerase-IIα (TOP2A) towards four novel Pd(II)-complexes bearing N,S-donor ligands. ...
Planejamento estrutural, modelagem molecular e síntese de complexos de cobre (ii) como potenciais inibidores da topoisomerase ii alfa humana
(Universidade Estadual Paulista (Unesp), 2021-03-05)
O câncer é considerado uma das principais causas de morte no mundo. É compreendido por mais de cem doenças que possuem características comuns, como a rápida proliferação celular e angiogênese. Embora haja fármacos disponíveis ...
Estrutura e função da proteína YacG de Klebsiella pneumoniae e seus derivados peptídicos
(Universidade Estadual Paulista (Unesp), 2015-02-26)
YacG belongs to zinc-finger's protein family discovered in E. coli. Its biological function is connected to the catalytic inhibition of DNA gyrase and stress metabolism in prokaryotes. This protein inhibits DNA gyrase ...
Síntese, caracterização estrutural e estudos do mecanismo de ação antitumoral de derivados indólicos
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Ciencias Farmaceuticas, 2018)
Compostos quelatos de paládio(II): Síntese, estudos de interação com biomoléculas e avaliação do potencial antitumoral contra células de câncer de mama
(Universidade Estadual Paulista (Unesp), 2021-06-04)
Apesar do sucesso da cisplatina como quimioterápico, o uso de compostos de PtII é limitado devido a sua toxicidade e resistência espontânea ou adquirida. Nesse caminho visando novos compostos biologicamente ativos destaca-se ...