Buscar
Mostrando ítems 1-10 de 18
Association of myelin peptide with vitamin D prevents autoimmune encephalomyelitis development
(2016-03-11)
Multiple sclerosis is a chronic, inflammatory and demyelinating disease of the central nervous system (CNS). As there is no cure for this disease, new therapeutic strategies and prophylactic measures are necessary. We ...
Vitamin D Deficiency and Rheumatoid Arthritis
(2017-06-01)
Vitamin D (VitD) is a hormone primarily synthesized in human skin under the stimulation of ultraviolet radiation. Beyond its endocrine role in bone metabolism, VitD is endowed with remarkable immunomodulatory properties. ...
Treatment with vitamin D/MOG association suppresses experimental autoimmune encephalomyelitis
(Public Library Science, 2015-05-12)
Experimental autoimmune encephalomyelitis (EAE) is an animal model to study multiple sclerosis (MS). Considering the tolerogenic effects of active vitamin D, we evaluated the therapeutic effect of myelin oligodendrocyte ...
Systemic Administration of Proteoglycan Protects BALB/c Retired Breeder Mice from Experimental Arthritis
(2016-01-01)
This study was undertaken to evaluate the prophylactic potential of proteoglycan (PG) administration in experimental arthritis. Female BALB/c retired breeder mice received two (2xPG50 and 2xPG100 groups) or three (3xPG50 ...
Obtenção de anticorpos monoclonais murinos reconhecedores de células tumorais prostáticas humanas
(Universidade Estadual Paulista (Unesp), 2017-04-06)
O câncer de próstata (CaP) é o mais diagnosticado e a segunda causa de morte por câncer entre os homens na América e nos países da Europa Ocidental. No Brasil, o número de novos casos de CaP estimado para o ano de 2016 foi ...
The Role of Secretory Leukocyte Proteinase Inhibitor During Transplantation
(Springer, 2019-01-16)
Purpose of Review: Old and new players of the innate immune response have been studied in the context of transplantation. Nonetheless, little interest has been focused toward the immune regulatory feedback in transplantation. ...
Potencial profilático de estratégias vacinais no diabetes experimental
(Universidade Estadual Paulista (Unesp), 2012-07-30)
O diabetes tipo I é uma doença causada pela destruição autoimune das células do pâncreas que resulta em deficiência na produção de insulina. O objetivo deste projeto foi, inicialmente, avaliar o potencial profilático de ...
Estratégias tolerogênicas antígeno-específicas visando profilaxia e terapia na artrite autoimune experimental
(Universidade Estadual Paulista (Unesp), 2014-07-30)
Rheumatoid arthritis (RA) is an autoimmune disease that affects the joints. Most of the therapies used for RA treatment are based on general suppression of immune response, which may increase the susceptibility to infectious ...
Potencial terapêutico de cisteína selenizada em modelo experimental de esclerose múltipla
(Universidade Estadual Paulista (Unesp), 2019-02-22)
A esclerose múltipla (EM) é uma doença inflamatória crônica e desmielinizante do sistema nervoso central (SNC). A imunopatogênese da EM envolve linfócitos Th1, Th17 e Tc autorreativos e ativação de macrófagos e microglia, ...