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Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?
(ELSEVIER, 2006)
Tumour necrosis factor (TNF), a cytokine mainly produced by macrophages, is associated with a broad spectrum of biological effects, mainly associated with the host defense against microbes. The TNF gene Is located on ...
Vitamin D decreases cell death and inflammation in human umbilical vein endothelial cells and placental explants from pregnant women with preeclampsia cultured with TNF-α
(2021-01-01)
This study evaluated the impact of vitamin D on Human Umbilical Vein Endothelial Cells (HUVEC) and inflammation in placental explants from women with preeclampsia (PE). HUVEC and explants from 10 late-onset PE (LOPE), 10 ...
Small Molecules as Anti-TNF Drugs
(Bentham Science Publishers, 2015)
Tumor necrosis factor (TNF, TNF-α, cachectin) is a pleiotropic, proinflammatory cytokine with multiple biological effects, many of which are not yet fully understood. Although TNF was initially described as an anti-tumor ...
Clinical parameters and biomarkers for anti-TNF treatment prognosis in rheumatoid arthritis patients
(International League of Associations for Rheumatology (ILAR), 2014)
Tumor necrosis factor (TNF) plays a pivotal role in
the pathogenesis of rheumatoid arthritis (RA). This finding
has led to the development of TNF blockers for RA treatment.
However, response to these therapies is ...
Mycobacterium bovis BCG but not Mycobacterium leprae induces TNF-alpha secretion in human monocytic THP-1 cells
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz., 2019)
Efeito da proteína de fusão ESAT6:CFP10 e do antígeno recombinante Rv1733 na modulação da produção de TNF- α e expressão de seus receptores em células RAW264.7
(Universidade Federal de Juiz de Fora (UFJF)BrasilICB – Instituto de Ciências BiológicasPrograma de Pós-graduação em Ciências Biológicas: Imunologia e Doenças Infecto-Parasitárias/Genética e BiotecnologiaUFJF, 2017)
TNF-alpha affects signature cytokines of th1 and th17 t cell subsets through differential actions on TNFR1 and TNFR2
(MDPI, 2022)
Tumor necrosis factor (TNF)- is a pleiotropic cytokine implicated in the etiology of
several autoimmune diseases, including rheumatoid arthritis (RA). TNF- regulates diverse effector
functions through the activation ...
TNF-α induces vascular insulin resistance via positive modulation of PTEN and decreased Akt/eNOS/NO signaling in high fat diet-fed mice
(BioMed Central, 2016)
Abstract
Background
High fat diet (HFD) induces insulin resistance in various tissues, including the vasculature. HFD also increases plasma levels of TNF-α, a cytokine that ...
Effect of TNF-alpha on molecules related to the Iinsulin action in endometrial cells exposed to hyperandrogenic and hyperinsulinic conditions characteristics of polycystic ovary syndrome
(Sage, 2018)
Polycystic ovary syndrome (PCOS) affects not only ovarian functions but is also able to affect endometrium metabolism. Around 80% of women with PCOS are obese. High tumor necrosis factor (TNF)- production and low adiponectin ...