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Prediction of the binding mode of N-2-phenylguanine derivative inhibitors to herpes simplex virus type 1 thymidine kinase
(Kluwer Academic PublDordrechtHolanda, 1998)
QSAR and molecular graphics analysis of N-2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases
(Elsevier Science IncNew YorkEUA, 2000)
Lipofection of early passages of cell cultures derived from murine adenocarcinomas: In vitro and ex vivo testing of the thymidine kinase/ganciclovir system
(Nature Publishing Group, 2002-12)
Early passages of cultured cells derived from four spontaneous Balb/c murine adenocarcinomas were used to explore the feasibility of a nonviral HSVtk-based suicide gene therapy system. After lipofection with pCMVtk, the ...
3D-Pharmacophore mapping of thymidine-based inhibitors of TMPK as potential antituberculosis agents
(SPRINGER, 2010)
Tuberculosis (TB) is the primary cause of mortality among infectious diseases. Mycobacterium tuberculosis monophosphate kinase (TMPKmt) is essential to DNA replication. Thus, this enzyme represents a promising target for ...
Conformational analysis and the active conformation of N-2-phenylguanine derivatives
(Elsevier Science BvAmsterdamHolanda, 2000)
A phase I clinical trial of thymidine kinase-based gene therapy in advanced hepatocellular carcinoma
(Nature Publishing Group, 2010-12)
The aim of this phase I clinical trial was to assess the feasibility and safety of intratumoral administration of a first-generation adenoviral vector encoding herpes simplex virus thymidine kinase (HSV-TK) gene (Ad.TK) ...