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Nicotinic receptor M3 transmembrane domain: Position 8′ contributes to channel gating
(American Society for Pharmacology and Experimental Therapeutics, 2002-08-01)
The nicotinic acetylcholine receptor (nAChR) is a pentamer of homologous subunits with composition α2βεδ in adult muscle. Each subunit contains four transmembrane domains (M1-M4). Position 8′ of the M3 domain is phenylalanine ...
Role of the cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors
(American Society for Biochemistry and Molecular Biology Inc., 2017)
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel ...
CALCIUM ACTIVATION OF K+ CHANNELS: RCK DOMAINS
(SPRINGER, 2013)
Some K+ channels can be activated by a rise in cytosolic Ca2+ and, in two cases (the K+ channels from the archeon Methanobacterium thermoautotrophicum (MthK) and the large conductance voltage- and Ca2+-activated K+ (BK) ...
Sequencing, bioinformatic characterization and expression pattern of a putative amino acid transporter from the parasitic cestode Echinococcus granulosus
(ELSEVIER, 2008-03-31)
We have sequenced and partially characterized an Echinococcus granulosus cDNA, termed egat1, from a protoscolex signal sequence trap (SST) cDNA library. The isolated 1627 bp long cDNA contains an ORF of 489 amino acids and ...
Immunoinformatic analysis of the whole proteome for vaccine design: An application to Clostridium perfringens
(Frontiers Media, 2022)
Clostridium perfringens is a dangerous bacterium and known biological warfare weapon associated with several diseases, whose lethal toxins can produce necrosis in humans. However, there is no safe and fully effective vaccine ...