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β-adrenergic stimulation controls the expression of a thioesterase specific for very-long-chain fatty acids in perfused hearts
(Academic Press Inc Elsevier Science, 2002-11)
Arachidonic acid is not freely stored in the cells. A number of different pathways for the mobilization of this compound have been proposed, including a novel mechanism that involves the release of arachidonic acid from ...
ACTH regulation of mitochondrial acyl-CoA thioesterase activity in Y1 adrenocortical tumour cells
(Taylor & Francis, 2002-11)
We have previously purified and cloned a phosphoprotein, Arachidonic acid-Related Thioesterase Involved in Steroidogenesis (ARTISt), involved in steroid synthesis through Arachidonic Acid (AA) release. Arachidonic acid-related ...
2-Bromopalmitate Reduces Protein Deacylation by Inhibition of Acyl-Protein Thioesterase Enzymatic Activities
(Public Library Science, 2013-10)
S-acylation, the covalent attachment of palmitate and other fatty acids on cysteine residues, is a reversible post-translational modification that exerts diverse effects on protein functions. S-acylation is catalyzed by ...
Macrodiolide Formation By The Thioesterase Of A Modular Polyketide Synthase
(Wiley-VCH Verlag, 2015)
The role of S-acylation in protein trafficking
(Wiley Blackwell Publishing, Inc, 2017-11)
Protein S-acylation, also known as palmitoylation, consists of the addition of a lipid molecule to one or more cysteine residues through a thioester bond. This modification, which is widespread in eukaryotes, is thought ...
Iterative Mechanism Of Macrodiolide Formation In The Anticancer Compound Conglobatin
(CELL PRESSCAMBRIDGE, 2015)
Arachidonic acid regulation of steroid synthesis: New partners in the signaling pathway of steroidogenic hormones
(Taylor & Francis, 2004-12)
Although the role of arachidonic acid (AA) in trophic hormone-stimulated steroid production in various steroidogenic cells is well documented, the mechanism responsible for AA release remains unknown. We have previously ...
The Autodepalmitoylating activity of APT maintains the spatial organization of Palmitoylated membrane proteins
(Cell Press, 2014-01)
The localization and signaling of S-palmitoylated peripheral membrane proteins is sustained by an acylation cycle in which acyl protein thioesterases (APTs) depalmitoylate mislocalized palmitoylated proteins on endomembranes. ...
Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation
(2012)
The first step in the penicillin biosynthetic pathway is the non-ribosomal condensation of l-α-aminoadipic acid, l-cysteine and l-valine into the tripeptide δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine (ACV). This reaction is ...